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中国科学院上海生命科学院 上海巴斯德研究所 孙兵教授 (Sun Bing, MD, Ph.D) 电话 :63851927, E-mail:bsun@sibs.ac

第十二章 超敏反应. 中国科学院上海生命科学院 上海巴斯德研究所 孙兵教授 (Sun Bing, MD, Ph.D) 电话 :63851927, E-mail:bsun@sibs.ac.cn. INTRODUCTION TO ALLERGY.

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中国科学院上海生命科学院 上海巴斯德研究所 孙兵教授 (Sun Bing, MD, Ph.D) 电话 :63851927, E-mail:bsun@sibs.ac

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  1. 第十二章 超敏反应 中国科学院上海生命科学院 上海巴斯德研究所 孙兵教授(Sun Bing, MD, Ph.D) 电话:63851927, E-mail:bsun@sibs.ac.cn

  2. INTRODUCTION TO ALLERGY • Hypersensitivity: Initially, human being contacts Ag (allergy) and becomes sensitization. Then the body has a high response to same allergy when it contacts with them in second time (through skin, mucosal or blood).

  3. THE IMMUNE SYSTEM CAN GO WRONG IN SEVERAL WAYS • Gell and Coomb’s classification of hypersensitivity (type I, II, III and IV) • “Allergy” is the commonest way that the immune system can go wrong

  4. GELL AND COOMB’SCLASSIFICATION OF THE HYPERSENSITIVIY STATES • TYPE 1 - IgE Ab mediated immediate reaction • TYPE 2 - IgG, M mediated Ab response • TYPE 3 - Immune complex • TYPE 4 - Delayed type hypersensitivity

  5. TB response ABO-red blood type Rhsus disease/Rh-M/with Rh+child Ab positive treatment

  6. General mechanism underlying a type I hypersensitive reaction.

  7. Components of Type I Reactions • ALLERGENS • REAGINIC ANTIBODY (IgE) • MAST CELLS AND BASOPHILS • IgE-BINDING Fc RECEPTORS

  8. When a substance is capable of producing allergic symptoms, it is known as an allergen.

  9. allergens

  10. Induction and regulation of IgE

  11. TH2 CELLS • Produce interleukins-4,5,10,13 • Important in inhibition of macrophage activation • Important in the the development of IgE responses (IL-4/IL-13) • Important in development of eosinophilia (IL-5)

  12. MAST CELLS AND BASOPHILS

  13. IgE Cross-linkage and Mast Cell Activation/Degranulation Antigen IgE Fc Receptor

  14. Late-Phase Reactions Induce Localized Inflammatory Reactions

  15. Type I Responses Are Regulated by Many Factors Antigen dosage Repeated low doses of an appropriate antigen induce a persistent IgE response in mice, but higher antigen doses result in transient IgE production and a shift toward IgG.

  16. TH1 and TH2 cytokines

  17. Regulatory T cells

  18. Therapeutic strategies for allergic diseases Dissociation of anti-inflammatory effects from side effects of corticosteroids.

  19. Inhibition of antigen-presenting cells (APCs) and Th2 lymphocytes.

  20. Inhibition of eosinophilic inflammation. Anti-histamine drug and immune modulator from Th2 switching to Th1.

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