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Rigour Mortis How bad research is killing science

Rigour Mortis How bad research is killing science. Malcolm Macleod Professor of Neurology and Translational Neurosciences University of Edinburgh and Honorary Consultant Neurologist, NHS Forth Valley Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies.

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Rigour Mortis How bad research is killing science

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  1. Rigour MortisHow bad research is killing science Malcolm Macleod Professor of Neurology and Translational Neurosciences University of Edinburgh and Honorary Consultant Neurologist, NHS Forth Valley Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies

  2. Purposes of an inaugural lecture • To try to explain to family and friends what it is that you actually do • To try to convince colleagues that what you do is actually useful • To try to encourage the next generation of researchers and teachers to improve on what you do

  3. What is translational neuroscience? My Definition: using information from one research domain to guide research in a different research domain I am not in the office at the moment. Send any work to be translated.

  4. Winner of the 2012 Ignoble Prize for Neuroscience

  5. What is a stroke? • Interruption of the blood supply to part of the brain • Stops that bit of the brain from working • The consequences depend on which part of the brain is affected • In a warning stroke the blockage is temporary • If the blockage is permanent that part of the brain dies • When this happens, other bits of brain can sometimes learn to take over some of the functions which have been lost

  6. A couple of important things about the brain …

  7. The burden of stroke • 5.5m people die worldwide each year – one every 6 seconds • ~150,000 per year in the UK • 40% of patients die • 30% become disabled as a result of their stroke

  8. 1026 Developing treatments for stroke Developed in in vitro and in vivo experiments O’Collins et al, 2006

  9. 603 1026 Developing treatments for stroke Tested in focal ischaemia O’Collins et al, 2006

  10. 374 883 1026 Developing treatments for stroke Effective in focal ischaemia O’Collins et al, 2006

  11. 550 883 1026 Developing treatments for stroke 97 18 Tested in clinical trial O’Collins et al, 2006

  12. 550 883 1026 Developing treatments for stroke 1 3 Effective in clinical trial O’Collins et al, 2006

  13. 10-120 M 10-60 M

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