Pre-Pharmacy Society umdprepharm@gmail studentorg.umd/prepharm

1. Pre-Pharmacy Societyumdprepharm@gmail.comstudentorg.umd.edu/prepharm Get on the ListServ...Join Our Facebook Group…Visit Our Website…CMNS Updates 6TH GENERAL BODY MEETING MAY 2, 2011

2. Welcome! Don’t forget to sign-in • Active Membership Requirements • Executive Board Elections! • Community Service Events • Sign Up! • Drug of the Week: PEMs • Summer Rx Opportunities presented by • Pre-Pharmacy Society Executive Board Agenda

3. 3 Meetings per semester • 3 Hours of Community Service per semester • Please do not wait until till the end of the semester to fulfill your community service hours • Exceptions will not be made Active Membership Requirements

4. President: Joseph Goble • VP of Student Affairs : Sandy Lim • VP of External Affairs: Krishna Dalsania • Secretary: Melissa Etchison • Treasurer: Edward Neuberger • Public Relations Co-Chair: Ben Moy • Public Relations Co-Chair: Long La • Community Service Co-Chair: SahilSheth • Community Service Co-Chair: Lauren Biagiotti Pre-Pharmacy Executive Board 2011-2012

5. When: Tomorrow, May 3rd, 4pm–8pm • Board Bus @ 3:45pm • UMB Pharmacy School Tour 5-7pm • Board Bus @ 7:15pm • Where: UMB School of Pharmacy • What: Private Pre-Pharmacy Society Tour! UMB Open House

6. Drug of the Week Protein Epitope Mimetics (PEM)

7. PEM are medium sized (0.7-2 kDa), fully synthetic cyclic peptide-like molecules that mimic the two most relevant secondary structure motifs involved in Protein-Protein Interactions (PPIs): The ß-hairpin and the α-helix. • Hence, PEM molecules can be viewed as functional minimizations of proteins. PEM are among the most potent and selective molecules known to modulate PPIs, GPCRs with large ligand-binding domains and enzymes. PEM Technology is, therefore, well suited to discover and optimize drug candidates that interfere with targets difficult to modulate with classical small molecule approaches Protein EpitopeMimetics (PEM)

8. POL7080 is a Pseudomonas specific antibiotic with a novel mode of action, (The antibiotics work by deactivating a protein vital for the formation of the bacteria's outer cell membrane.) • POL7080 is the first of a new class of antibiotics derived from the PEM Technology platform. In preclinical studies the compound was highly active on a broad panel of clinical isolates including multi-drug resistant Pseudomonas bacteria with outstanding in vivo efficacy in septicemia, lung and thigh infection models. Its novel mode of action has been published in Science One type: Antibiotic POL7080

9. Gram Positive Gram Negative Cytoplasmic Membrane Outer Membrane Peptidoglycan cytoplasm cytoplasm

10. Some Antibacterial Compounds Weaken Peptidoglycan x x Penicillin Lysozyme blocks peptide crosslinking Cleaves NAG- NAM bonds

11. Researchers from a privately held Swiss biotech company Polyphor and the University of Zurich said the potential medicines are effective against a type of bacteria known as "gram-negative," and offer hope for new treatments for serious and often life-threatening infections, (specifically those that cause lung infections). • A report in December found that gram-negative bacteria account for around 63 percent of infections in hospital intensive care units. Experts commenting on that study said they feared resistance among gram-negative bugs was rising while the number of medicines to treat them was shrinking. • Drug of the future? Why Important?

12. Drug-resistant bacteria kill about 25,000 people a year in Europe and about 19,000 in the United States. • Polyphor is planning to start Phase I clinical trials in healthy volunteers in the second quarter of this year and had begun out-licensing negotiations with potential pharma partners. Additional Information

13. http://www.polyphor.com/pemfinder%C2%AE-platform.html • http://www.reuters.com/article/2010/02/18/us-antibiotics-superbugs-idUSTRE61H5NI20100218 • Fasan, R., Dias, R., Moehle, K., Zerbe, O., Obrecht, D.,Mittl, P., Grutter, M.P., and J.A. Robinson. 2006. Structure–Activity Studies in a Family of b-Hairpin Protein Epitope Mimetic Inhibitors of the p53–HDM2 Protein–Protein Interaction. ChemBioChem. 7:515–526. Sources

14. Pharmaceutical Issue Should birth control be available to women (16 years old or older) without a prescription?

15. Pharmacy Access Amendment Act: would give the Board of Pharmacy and the Board of Medicine authorization to set up guidelines for consumers to pick up birth control without going to the doctors office (proposed bill as of February 2011) • Would allow pharmacists to prescribe birth control to certain women Legislation

16. “Pharmacists are extraordinarily overeducated for what they do on a day-in and day-out basis. There is a lot of capacity for a pharmacist to do more than they do.” • Logically, most pharmacists, who possess skills far beyond putting pills in bottles should be more than capable of asking a patient questions and assessing whether hypertension, a history of heart disease, and other factors should prevent that patient from going on birth control. Under this bill, they would do just that, and write or not write a birth control prescription.

17. Expand access to contraception • Conserve valuable resources and reduce costs • Greater health care options for thousands of women • Prevent unnecessary doctors visits in an already overcrowded healthcare system Pros

18. This bill would just be the first step in implementing a program like this • This program would only be available to women who do not smoke or have hypertension • Unsure whether a program like this would actually work Cons

19. Should pharmacists be able to prescribe women with birth control? • Is it a health risk for women to not be screened by a doctor before receiving birth control? • Would this lead to promiscuity in young girls? • Is this any different from acquiring the “morning after” pill? Discussion

20. http://dailycaller.com/2011/02/16/dc-pharmacists-to-start-dispensing-birth-control/http://dailycaller.com/2011/02/16/dc-pharmacists-to-start-dispensing-birth-control/ • http://www.washingtoncitypaper.com/blogs/citydesk/2011/02/22/catanias-over-the-counter-birth-control-isnt-actually-over-the-counter/ • http://www.washingtoninformer.com/index.php?option=com_content&view=article&id=5521:catania-birth-control-bill-comes-under-scrutiny&catid=50:local&Itemid=113 Sources

21. Pre-Pharmacy Society Proudly Presents… Summer Rx Opportunities!!!

22. Intern Health Management Services • Type: Internship • Location: Arlington, VA • Point of Contact: NRECA – General Inquiries(703) 907-5500 • Minimum Hours Requirement: No

23. Provide a summer intern with an opportunity to gain knowledge and experience working in the Health Management Services department • There are several projects an intern will assist with this summer including: 1. Revision of existing EAT SMART Kit (which requires updating per the release of the new USDA Dietary Guidelines) 2. Wellness audits (co-ops’ wellness programs are audited once every 4 years for compliance with program parameters) 3. Supporting the Pharmacy Benefits group (e.g. updating Commercial and Medicare Part D tracking document, organizing Medicare Part D letter project) 4. Review and recommendations of Reuters articles for posting on MyHealth Online Additional Information

24. Rising college junior or senior with: 1. Track record of academic achievement 2. Knowledge, background and experience or major field of study in: • Health Promotion, Nutrition, Nursing or Marketing/Communication 3. Ability to be very detailed oriented 4. Ability to be very organized 5. An energetic personality 6. Ability to multi-task and work on several projects at once Who Can Apply?

25. All candidates must apply on-line at www.nreca.jobs to be considered. More Questions?

26. MedImmune • Type: Internship • Location:  Gaithersburg, MD • Minimum Hours Requirement: N/A • To apply: • 1. Visit www.medimmune.com • 2. Search REQ# ID: 5297 under Careers tab • 3. Fill out personal profile (including resume)

27.  Duties and Responsibilities: • literature searches • assessment of novel drug delivery technologies • feasibility studies on novel/traditional drug delivery systems in a lab setting • At the end of internship, present findings on a poster Internship: Drug Delivery and Devices

28. Requirements: • currently enrolled as an undergraduate/graduate with engineering, pharmacy, pharmaceutical science, biology or other relevant background  • minimum one year of undergrad education complete •  Applicants considered for multiple position vacancies for which they are qualified, so only one profile needs to be completed • Any questions/assistance on application process: • Medimmune Recruiting Desk • (1866)428-9942

29. Children’s National Medical Center • Type: Internship/Volunteer • Location: Children's National Medical Center • 111 Michigan Ave, NW, Washington DC • Point of Contact: Eric P. Hoffman • 202-476-6029 ehoffman@cnmcresearch.org • Minimum Hours Requirement: N0

30. Go to:  http://www.childrensnational.org/research/OurResearch/ • Center for Neuroscience • Center for Clinical and Community Research • Center for Cancer and Immunology Research • Center for Genetic Medicine Research • Center for Molecular Physiology Research Research Fields

31. Asthma and lung disease  • Diabetes  • Inborn errors of metabolism  • Macular degeneration  • Muscular dystrophies  • Sickle cell disease  • Obesity and metabolic syndrome  • White Matter Disease Center for Genetic Medicine Research--> Click any of following links and email lead researcher

32. Very pertinent experience •  New lab starting this summer with awesome technology! • Paid or Unpaid, but great experience, mentors, and probably recommendation regardless • Commute • Mice testing •  Interview- Be sure to express why your interested/be enthusiastic • Ask questions • Mostly tour and meeting of lead researcher • Dress up, Bring resume • Talk about experiences in Biology/Chemistry Labs Information

33. University of Maryland Medical Center • Type: Volunteer • Location: 29. S Greene Street, Baltimore • Phone: 410-328-5600 for any questions • Min. Hours Requirement: Yes; at least 4 hours during a regular time slot

34. Complete the volunteer application and turn it into the volunteer office. Fax number is 410-328-2924. • Once you have completed the necessary paperwork, return it to the volunteer office and call (410) 328-5600 to schedule your interview. No interviews until June. • Complete the health form, and bring in documentation of your immunization records. If you don't have any proof of your immunization, you may need to have your blood drawn. • Complete a mandatory orientation (see orientation checklist) and annual training session. Process

35. Application - http://www.umm.edu/resources/volunteer_application.pdf • Health Form- http://www.umm.edu/resources/medical_form.pdf • Orientation Checklist - http://www.umm.edu/resources/vol_serv.htm#volunteer Links to Forms:

36. In order to get an evaluation, certificate or letter of recommendation, you must complete at least 75 hours of volunteer service in one department. • The 75 hours of service must be completed consecutively from the start date. Regular attendance ensures that volunteers get fully trained and get to know the staff that they work with. It also enhances the volunteer experience and enables volunteers to make a real contribution to their unit or department. Reference Request

37. Type: Volunteer • Location: University Health Center • On campus! • Point of Contact: Elizabeth Zapata •  (301)314-8095 •  zapata@health.umd.edu • Minimum Hours Requirement: 3 to 4 hr/week (min 2 hr shift)at least 40 hr/semester UMD Health Center Pharmacy

38.  Application Process: FIRST COME FIRST SERVED! •  Email Elizabeth Zapata 4 weeks prior to start of semester • Resume • Class Schedule • Personal Statement • Only 25 new volunteers per semester in Health Center • Once you are chosen as a volunteer: • HIPAA training • Orientation in the Pharmacy • For more information, visit: • http://www.health.umd.edu/becoming-a-volunteer More Information

39. Provide patients with OTC medicines • Provide patients with their prescriptions and take payments • If Pharm Tech certified: prepare and handle medications • Gain valuable experience for your application! What you'll do as a Volunteer

40. Washington Hospital Center • Type: Volunteer  • Location: Washington, DC • Point of Contact: (202) 877-3192 • Minimum Hours Requirement: No

41. Requirements: •  Must complete online application at http://whc.jobs/ •  Interview • A reference letter from a professional source • One page summary about you, career plants/interests, and why you want to volunteer Becoming A Volunteer

42. Main Phone: (202) 877-7000 • Washington Hospital Center      110 Irving Street NW     Washington, DC 20010 • For more information, visit: http://www.whcenter.org/body.cfm?id=1277 Contact Information

43. The George Washington University Hospital • Type: Volunteer • Location: Right when you get off the Metro at the Foggy Bottom-GWU stop • Point of Contact: Volunteer Office- (202) 715-4188 • Minimum Hours Requirement: Yes- 4 hours a week for 6 months or 100 hours total • More Information: •         1. www.gwhospital.com/Volunteering

44. Requirements • must be 18 or older • submit an online application • background check • Physical • drug screen • orientation prior to start date • If you have questions, call 202-715-4188 or submit an email through a form that they provide

45. Get paid, real-time experience •  Locations: Retail Pharmacies, Hospitals, Clinics, Grocery stores, NIH? FDA? •  Get approved First! •  www.PTCB.org •  Study and take the examination on a scheduled date • Apply for an approval from PTCB  • Contact and inquire your desired work location Pharmacy Technician

46. More Information: 1. For an application for Board approval:  www.dhmh.maryland.gov/pharmacyboard/license/tech/index.htm 2.After a successful examination, you earn a 'CPhT' after your name More Information

47. Johns Hopkins Hospital • Type: Work as a Pharmacy Technician • Location: Pharmacy Department at Johns Hopkins Hospital in Baltimore, MD (Carnegie Building). • Point of Contact: 410-614-5611  • Minimum Hours Requirement: No

48. Need to be certified! • More Information: • www.hopkinsmedicine.org/pharmacy  • REQ ID:32769 Other Requirements

49. THE END! THE END! Pre-Pharmacy Societyumdprepharm@gmail.comstudentorg.umd.edu/prepharm Get on the ListServ...Join Our Facebook Group…Visit Our Website…CMNS Updates THE END! THE END! 6TH GENERAL BODY MEETING MAY 2, 2011