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Explore cutting-edge wound care, tissue regeneration, and biomaterials for burn injuries and chronic wounds. Collaboration with leading experts in biomedicine and biomaterial science.
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Wound Healing, Tissue Engineering and New Materials Roger W. Yurt, M.D. William Randolph Hearst Burn Center
Burn Center • Clinical care of burn injured patients including smoke inhalation and carbon monoxide poisoning • Clinical care of patients with acute and chronic wounds – eg, purpura fulminans • Clinical care of patients with exfoliating skin disease - TENS
(Partial thickness) Superficial Deep (Full thickness)
Wound Closure • Life-saving - large surface areas, closure ASAP • Cosmetic - life time deficits/defects • Function – joint, tactile, sight, oral
Life-saving Excise &Autograft Excise & Allograft Recrop Autograft Excise & Allograft Recrop Autograft
Life-saving Excise &Autograft Excise & Integra Recrop Autograft Excise & Allograft Recrop Autograft
Integra – Dermal Regeneration Template Collagen, glycosamino- glycan matrix Silastic membrane
Collaboration with School of Chemical and Biomolecular Engineering • Abraham Stroock • Microfluidic wound dressings • Cabodi M et al J. Biomedical Materials Research
Concept – Active Dressing Dressing • vapor barrier • mechanical barrier Inputs Outputs • hydration • sanitation • drug delivery • gene delivery • diagnostics • patient profiling • biochemical analysis Interface flow • biochemical regulation • mechanical stimulation • perfusion of tissue wound bed
Technical Approach: “Soft Lithography” silicone monomer micro-mold micro-molding polymerization release release photo-patterning sealing fluidic connections UV light
Function – Extraction Extraction
Function – Delivery Delivery
Collaboration with College of Human Ecology • C.C. Chu • Department of Fiber Science and Apparel Design
Newly Invented Biodegradable Biomaterials: Poly(ester-amide) (PEA) An example of PEA: amino acids as main building blocks An elastomer: biodegradable rubber band C. C. Chu, et al., US Patent 6,503,538, January 7, 2003
Electrospun PEA Fibrous Mat 1 inch Video insert
SEM Image of 3D Microporous PEA Fibrous Structure PEA control (no GN) PEA w/ GN loaded Fiber diameter: 1/100 – 3/100 of human hair
Collaboration with the Department of Biomedical Engineering • Moonsoo Jin, C.C. Chu • A novel growth factor and matrix mimetic-enhanced biodegradable scaffold for skin tissue engineering
Collaboration with the Department of Biomedical Engineering • Recently funded seed grant • Jin –growth factors, matrix-mimetic production, conjugation and cell culture • Chu – 3 dimensional PEA scaffold design and fabrication • Burn Center – animal laboratory and clinical application
Burn Research Team • Palmer Q. “Joe” Bessey, M.D. • Joe Turkowski, M.D. • Suzanne Schwartz, M.D. • Research co-ordinators: Nicole Alden, RN, MPH Angela Rabbitts, RN, MS