Ivivc - A Tool for in vitro- in vivo Correlation Exploration with R

Oct 06, 2012

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Ivivc - A Tool for in vitro- in vivo Correlation Exploration with R

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In-Vitro-In-Vivo Correlation (IVIVC): A Tool In drug Development

In-Vitro-In-Vivo Correlation (IVIVC): A Tool In drug Development . Mr. Somnath Sakore Cadila Pharmaceuticals Ltd . Outline. Definition of IVIVC Purpose of IVIVC Levels of IVIVC In vitro data In vivo data IVIVC models IVIVC development Predictability

3.71k views • 24 slides

Dose extrapolation from in vitro to in vivo and across species

Dose extrapolation from in vitro to in vivo and across species. Pierre-Louis Toutain Royal veterinary College London & project officer at the ENV of Toulouse. Wuhan University October 2017.

1.23k views • 105 slides

Models for in vivo and in vitro studies on basophils

Models for in vivo and in vitro studies on basophils . Trainer: Franco Falcone. Introduction. Basophils were discovered more than century ago (1879) Only recently they have been identify to play a role in allergy (1972)

399 views • 21 slides

Antimicrobial agent in vivo vivo inside the body vitro out side the body

Antimicrobial agent in vivo vivo inside the body vitro out side the body. Chemotherapeutic agent use chemical to treat any disease or condition. Antimicrobial agent drugs used to treat an infections disease either by inhibiting or killing Pathogens in vivo. Antibacterial

213 views • 9 slides

Advantages of in vitro vs in vivo

Advantages of in vitro vs in vivo. Sort them out! Useful for introducing genes into other organisms. Does not require living cells Can isolate one specific gene It is very accurate It is extremely rapid Almost no risk of contamination Can produce large quantities of gene products.

861 views • 30 slides

A Seminar on In vitro In vivo Correlation

A Seminar on In vitro In vivo Correlation. By Bollepalli Anusha ( M pharm I sem ) Department of Pharmaceutics Blue Birds College of Pharmacy (Affiliated to Kakatiya University) Bheemaram, Warangal. CONTENTS. Introduction Biopharmaceutical classification system In vitro studies

1.43k views • 27 slides

Vector Claims in Gene Therapy Applications: In vivo vs. In vitro Utilities

Vector Claims in Gene Therapy Applications: In vivo vs. In vitro Utilities. Deborah Reynolds SPE GAU 1632 703-305-4051. 35 U.S.C. § 112, first paragraph.

325 views • 20 slides

In Vitro models of Infections: the postantibiotic and sub-MIC effects in vitro and in vivo

In Vitro models of Infections: the postantibiotic and sub-MIC effects in vitro and in vivo. Inga Odenholt, MD., Ph.D. Department of Infectious Diseases University hospital Malmö Sweden. Pharmacodynamic parameters. Postantibiotic effect (PAE) In vitro In vivo Postfungal effect (PAFE)

946 views • 62 slides

Identification of metabolites of actinomycin-D in vivo and in vitro

Structure of Actinomycin-D. Hydroxylation (M+H) + = 1271. Sulfonation (M+H) + = 1351. Glucuronidation (M+H) + = 1457. Peptide Cleavages (M+H) + = 327. Cyclic Peptide Cleavage (M+H) + = 971. Peptide Bond Cleavage (M+H) + = 1273.

142 views • 1 slides

DC beads loaded with Irinotecan : precilinical in-vitro & in-vivo evaluation

DC beads loaded with Irinotecan : precilinical in-vitro & in-vivo evaluation. T de Baere. Bench top Animal model. Colorectal cancer chemotherapy. % response rate. FOLFIRI. FOLFOX. LV5FU2. 5FU-FA. 55 %. 55 %. 5 FU. 25 %. 20 %. 10 %. Sytemic therapy.

413 views • 25 slides

Sub-MIC effects in vitro and in vivo

Sub-MIC effects in vitro and in vivo. Inga Odenholt, MD., Ph.D. Department of Infectious Diseases University hospital Malmö Sweden. Pharmacodynamic indices. Postantibiotic effect (PAE) In vitro In vivo Postfungal effect (PAFE) Postantibiotic sub-MIC effect (PA SME) In vitro In vivo.

796 views • 52 slides

Evaluation of the novel nanocell (in vitro/in vivo)

Evaluation of the novel nanocell (in vitro/in vivo). Dr.Ramraj Panthee Chulabhorn Research Institute. Outline. Introduction In vitro studies In vivo studies Summary. Introduction. Novel nanocell Confocal microscope In vitro Cell culture studies Co- culture studies

363 views • 22 slides

Understanding Concepts and Regulatory Compliance Requirements for in Vitro-in Vivo Correlations

47 views • 3 slides

In vitro - in vivo correlation and biopharmaceutical classification system (bcs): A review

In vitro dissolution has been extensively used as a quality control tool for solid oral dosage forms. In several cases, however, it is not known whether one can predict the in vivo performance of these products from in vitro dissolution data. In an effort to minimize unnecessary human testing, investigations of in vitro / in vivo correlations (IVIVC) between in vitro dissolution and in vivo bioavailability are increasingly becoming an integral part of extended release (ER) drug product development

275 views • 12 slides

LOOKING FOR LIPID PEROXIDATION IN VITRO AND IN VIVO : IS SEEING BELIEVING?

LOOKING FOR LIPID PEROXIDATION IN VITRO AND IN VIVO : IS SEEING BELIEVING? Vanderbilt University School of Medicine Jason D. Morrow MD. Question?.

649 views • 62 slides

Evaluation of the novel nanocell (in vitro/in vivo)

248 views • 22 slides

Phenylbutyrate increases SMN gene expression in vitro and in vivo

Phenylbutyrate increases SMN gene expression in vitro and in vivo. Christina Brahe. Università Cattolica del S.Cuore, Roma. SMA is caused by homozygous absence of the SMN1 gene. SMN1. SMN2. tel. cen. SMA patients have one or more SMN2 genes which modulate the disease severity.

203 views • 19 slides

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Ivivc - A Tool for in vitro- in vivo Correlation Exploration with R

Ivivc - A Tool for in vitro- in vivo Correlation Exploration with R

Presentation Transcript

In-Vitro-In-Vivo Correlation (IVIVC): A Tool In drug Development

Dose extrapolation from in vitro to in vivo and across species

Models for in vivo and in vitro studies on basophils

Antimicrobial agent in vivo vivo inside the body vitro out side the body

Advantages of in vitro vs in vivo

A Seminar on In vitro In vivo Correlation

Vector Claims in Gene Therapy Applications: In vivo vs. In vitro Utilities

In Vitro models of Infections: the postantibiotic and sub-MIC effects in vitro and in vivo

Identification of metabolites of actinomycin-D in vivo and in vitro

DC beads loaded with Irinotecan : precilinical in-vitro &amp; in-vivo evaluation

Sub-MIC effects in vitro and in vivo

Evaluation of the novel nanocell (in vitro/in vivo)

Understanding Concepts and Regulatory Compliance Requirements for in Vitro-in Vivo Correlations

In vitro - in vivo correlation and biopharmaceutical classification system (bcs): A review

LOOKING FOR LIPID PEROXIDATION IN VITRO AND IN VIVO : IS SEEING BELIEVING?

Evaluation of the novel nanocell (in vitro/in vivo)

Phenylbutyrate increases SMN gene expression in vitro and in vivo

DC beads loaded with Irinotecan : precilinical in-vitro & in-vivo evaluation