Trinity Centre for Bioengineering Seminar

1. Trinity Centre for Bioengineering Seminar Advances in Skeletal Fluorescence Imaging NEURAL ENGINEERING REGENERATIVE MEDICINE Date: Tuesday 4 Sept 2012 Time: 4.00pm Venue: Crosslands Theatre, Parsons Building Trinity College Dublin BIOMATERIALS Ken Kozloff, PhD Dept. of Orthopaedic Surgery & Biomedical Engineering University of Michigan, Ann Arbor, MI USA MUSCULOSKELETAL CARDIOVASCULAR www.tcd.ie/bioengineering email: tcbe@tcd.ie

2. Trinity Centre for Bioengineering Seminar NEURAL ENGINEERING Abstract Fluorescence imaging techniques have been applied to the skeleton since Frost popularized the use of tetracyclines to quantify bone dynamics in the 1960’s. Until recently, tissue autofluorescence has limited the use of fluorescent bone markers to histologic observations based on bone biopsy or destructive sample sectioning. The advent of near-infrared fluorescent contrast agents and imaging systems has expanded the use of fluorescence to non-invasive, in vivo systems, and has facilitated significant progress in the development and application of novel probes for interrogating cell function. My laboratory has been exploring the use of a “fluorescent toolkit” to visualize osteoblast and osteoclast activity in the context of local skeletal drug delivery in the skeleton. Combining fluorescence with micro-computed tomography and biomechanical testing, my laboratory focuses on understanding how emerging therapeutics designated to regulate bone metabolism can influence the long-term skeletal health in diseases of genetic, hormonal, or mechanical origin. Biosketch Ken Kozloff, PhD, is an Assistant Professor in the Departments of Orthopaedic Surgery and Biomedical Engineering at the University of Michigan. He was educated at the University of Michigan, receiving a bachelors degree in Materials Science and Engineering in 1997, followed by masters degrees in Mechanical and Biomedical Engineering. Dr. Kozloff received his PhD in Biomedical Engineering from the University of Michigan in 2005, investigating the skeletal phenotype of the Brtl/+ knock-in mouse model for osteogenesisimperfecta. Dr. Kozloff performed postdoctoral training at Harvard Medical School in Boston, first at the Center for Molecular Imaging Research at Massachusetts General Hospital, and then in the Bone Cell Biology Laboratory at Boston Children’s Hospital. Dr. Kozloff joined the faculty of the Orthopaedic Research Laboratories at the University of Michigan in 2007. Dr. Kozloff’s research interests include molecular imaging of bone structure, metabolism, and skeletal drug delivery, diseases of low bone mass and therapeutic options, and factors governing both fracture susceptibility and skeletal repair. Contact Information: kenkoz@umich.edu www.umich.edu/~skeleton REGENERATIVE MEDICINE BIOMATERIALS MUSCULOSKELETAL CARDIOVASCULAR www.tcd.ie/bioengineering email: tcbe@tcd.ie