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Circulation 2001;104:2632-2634.

Circulation 2001;104:2632-2634. Time from Symptom Onset to Study Treatment in Large Scale Thrombolytic Trials. 2.8. 2.7. 2.9. 2.8. 2.7. 2.7. Median Time (hrs) Between Symptom Onset and Treatment. ASSENT 3 00-01. GUSTO V 99-01. ASSENT II 97-98. GUSTO I 90-93. GUSTO III 95-97.

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Circulation 2001;104:2632-2634.

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  1. Circulation 2001;104:2632-2634.

  2. Time from Symptom Onset to Study Treatment in Large Scale Thrombolytic Trials 2.8 2.7 2.9 2.8 2.7 2.7 Median Time (hrs) Between Symptom Onset and Treatment ASSENT 3 00-01 GUSTO V 99-01 ASSENT II 97-98 GUSTO I 90-93 GUSTO III 95-97 InTIME II 97-99 Gibson CM, Circulation 2001;104:2632-2634

  3. Benefits of PCI vs Lysis: The Importance of Timing Kent DM et al Eff Clin Pract 4: 214, 2001

  4. Primary PCI for STEMITime to Reperfusion and 30 Day Mortality CADILLAC Zwolle N= 2002 N= 1791 1994-2001 9.6 P=0.04 (< 3h v > 3 h) P < 0.001 % Mortality 5.6 2.3 2.2 3.1 2.5 0.9 Cox ACC ‘03 Abst 827-1 DeLuca ACC ‘03 Abst 827-3 Time to Reperfusion (h)

  5. NRMI-2: Primary PCI Door-to-Balloon time vs. Mortality N=27,080 P < 0.00001 Door-to-Balloon Time (minutes)

  6. Door to Balloon Times Among Patients Transferred in NRMI 4 Data to Cath Lab Arrival: 50th: 137 Min. 25th: 87 Min. 75th: 220 Min. Cath Lab to Balloon: 50th: 39 Min. 25th: 29 Min 75th: 53 Min. Door to Data: 50th: 8 Min. 25th: 4 Min. 75th: 16 Min. 8 137 39 Total Door to Balloon Time: 198 minutes (25th: 137; 75th: 281) Percent of Patients with Door to Balloon Time < 90 Min.: 4.8% Sample Size: 1,292; Time Period: October 2000 – September 2001 NRMI 4 Transfer-In Annual Data Report 2002 Gibson 2003

  7. DANAMI vs US AMI: Are We As Quick In The US? 198 Min. 110 Min. 90 Min. Median Time (Min.) US AMI Transfer 1o PCI DANAMI Transfer 1o PCI DANAMI On Site 1o PCI

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