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Core structures within the PTP domain are highly conserved and

IV M x T (M6). K Cxx Y WP (M7). W PDxGx P (M8). TxxD FW xMxW (M5). QTxx Q Y x F (M10). Pxx V HCS A G x GR T G (M9). IAx Q GP (M4). D xxRVx L (M2). N xx K N R Y (M1). D Y INA (M3). Core structures within the PTP domain are highly conserved and

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Core structures within the PTP domain are highly conserved and

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  1. IVMxT (M6) KCxxYWP (M7) WPDxGxP (M8) TxxD FWxMxW (M5) QTxx QYxF (M10) PxxV HCSAGxGRTG (M9) IAxQGP (M4) DxxRVxL (M2) NxxKNRY (M1) DYINA (M3) Core structures within the PTP domain are highly conserved and surface loops between secondary structure elements are least conserved Ribbon diagram indicating the position of conserved motifs (M1-M10) within the tertiary structure of PTP1B (blue - most conserved; red - least conserved). http://ptp.cshl.edu & http://science.novonordisk.com/ptp Andersen et al Mol. Cell. Biol. 2001

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