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Bone Marrow (Osteoblastic Zone). CXCR4. c-Kit +. SDF-1, VEGF. Sinusoidal Vessel. Ischemic/ Tumor Tissue. MMP9. Estrogen Hypoxia. MMP9. NO. eNOS. Bone Marrow Stromal Cell. PI3K. SDF-1, VEGF. Membrane-bound Kit Ligand (m-KitL). Bone Marrow Stromal Cell. Endothelial Progenitor Cell.
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Bone Marrow (Osteoblastic Zone) CXCR4 c-Kit+ SDF-1, VEGF Sinusoidal Vessel Ischemic/ Tumor Tissue MMP9 • Estrogen • Hypoxia MMP9 NO eNOS Bone Marrow Stromal Cell PI3K SDF-1, VEGF Membrane-bound Kit Ligand (m-KitL) Bone Marrow Stromal Cell Endothelial Progenitor Cell Soluble Kit Ligand (s-KitL)