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Journal Club 2

Journal Club 2. Olga Filippova, Munir Nahri, Akash Patel Group 1. Liver Introduction. Lobules Functional Unit Vascular Triads Hepatocyte Plate Sinusoids.

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Journal Club 2

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  1. Journal Club2 Olga Filippova, Munir Nahri, Akash Patel Group 1

  2. Liver Introduction • Lobules • Functional Unit • Vascular Triads • Hepatocyte Plate Sinusoids

  3. Intro to Liver – sinusoids, hepatocyte role in drug metabolism, urea’s connection to drug metabolism, endothelia – hepatocyte signaling for drug metabolism • Matrigel – composition (IV, laminin), pros (thermal crosslinking, differentiation) + cons (low shear + young’s, little proliferation), • Current Trends - Free-form fabrication (computer aided for reproducibility, mass printing), • Hypothesis – computer aided 3D free-form fabrication of co-cultured cell-laden Matrigel constructs for improved in vitro pharmacokinetic model • Control (AH, AHE), Experimental (MH, MHE) • Temperature controlled environment is necessary for proper matrigel printing • Improving a current model • Intro to Paper – similar alginate model but only H, simple diagram,

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