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2008/05/02 何積泓

2008/05/02 何積泓. Oxidative Stress. Reactive oxygen species (ROS) Oxygen ions Free radicals Peroxides Antioxidant defense Damage sperm membrane and motility Alter sperm DNA and initiate apoptosis. Male infertility. Half of all cases of infertility Affects one man in 20

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2008/05/02 何積泓

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  1. 2008/05/02 何積泓

  2. Oxidative Stress • Reactive oxygen species (ROS) • Oxygen ions • Free radicals • Peroxides • Antioxidant defense • Damage sperm membrane and motility • Alter sperm DNA and initiate apoptosis

  3. Male infertility • Half of all cases of infertility • Affects one man in 20 • Reduction in seminal plasma and spermatozoa glutathione peroxidase • Reduction in non-enzymatic antioxidant activity in seminal plasma • IUI or ICSI, not for oxidative stress

  4. Leukocyte • Positive correlation between seminal leukocytes number and ROS production • No significance difference between fertile and infertile men • Positive correlation between seminal ROS and cytokines (IL-6, IL-8, TNF-α)

  5. Sperm • ROS assists the sperm’s transit through the cumulus and zona pellicida • ROS production ability inversely correlates with maturation state • Excess cytoplasmic residues in the mid- piece are rich in G6PD  NADPH production • Produce less ROS (1/1000) but cause more DNA damage

  6. Identification of oxidative stress • The cost and complexity of testing • The lack of a single standardized measure of oxidative stress • Direct method: damage created by ROS • Indirect method: ROS production • Routine semen analysis: asthenozoospermia, hyperviscosity of seminal plasma, seminal leukocytes, poor sperm membrane integrity

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