1 / 1

Plasma Membrane

Graphical Abstract. Plasma Membrane. Inhibition of ATPase domain of Hu-TopoII α leads to DNA damage. (1,4-benzoquinone or 1,4-naphthoquinone , 1,2-naphthoquinone or 9,10-phenanthroquinone). Cytoplasm. TopoII α -DNA complexes. Topo II cleaves DNA and religates using ATP. DNA DSBs.

rue
Download Presentation

Plasma Membrane

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Graphical Abstract Plasma Membrane Inhibition of ATPase domain of Hu-TopoIIα leads to DNA damage (1,4-benzoquinone or 1,4-naphthoquinone , 1,2-naphthoquinone or 9,10-phenanthroquinone) Cytoplasm TopoIIα-DNA complexes Topo II cleaves DNA and religates using ATP DNA DSBs Nucleus Topo II binds to DNA Histones DNA Repair Phosphorylation of histones Cell Survival DNA damage, chromosomal aberrations P P P P Cancer

More Related