Aulanni’am Biochemistry Laboratory Chemistry Departement Brawijaya University

1. Vitamin and mineral Aulanni’am Biochemistry Laboratory Chemistry Departement Brawijaya University Aulani " Biokimia" Presentation 10

2. Recommened Daily Intake • Recommended daily intake (RDI) is the amount that satisfies the majority of healthy individuals within the population. • RDI can be used as a referent when; developing menus, for food counseling, evaluating questionnaire for food consumption, and occasionally to estimate food consumption on an individual basis. Aulani " Biokimia" Presentation 10

3. Vitamin • Definition: Essential organic substance from the food that is important in small amount for the metabolism and function of the body. • Exists in most food types • Most of the vitamins play an important role in the body • Decreased health status can be noticed with limited or excessive intake – deficiency vs. toxicity Aulani " Biokimia" Presentation 10

4. Vitamin and mineral absorption • Depends on • Our nutritional status • Other food items that is consumed at the same time • Type of cocking method used • Chemical state of nutrient • The speed of digestion • The quality of absorption • How the vitamin and mineral is absorbed • NOTE that all of the issues mentioned above are taken into consideration when evaluating the RDI Aulani " Biokimia" Presentation 10

5. Vitamin • Water-soluble vitamin • Vitamin B • Thiamin (B1), Riboflavin (B2), Niacin, Pyridoxin (B6), Folate, Cobalamin (B12), Pantothenic acid, Biotin • Vitamin C Aulani " Biokimia" Presentation 10

6. Vitamin B • They all interact with the energy metabolism in one way or another • The water soluble vitamin absorbs easily from the intestine as well as they are easily discreted from the kidney. • Heat therapy, light and storage or radiation can decrease considerably the amount of water soluble vitamins in food Aulani " Biokimia" Presentation 10

7. Vitamin B • Thiamine (B1) is a co-enzyme in energy metabolism, an important part of the nerve cells • Deficiency: Beri-beri • Food: found in various food items such as pork, green leafy vegetables, whole corn and beans. • Riboflavin (B2) is a co-enzyme in the respiratory chain • Deficiency: skin rash • Food: Milk and milk products, liver, green leafy vegetables, corn and meat Aulani " Biokimia" Presentation 10

8. Vitamin B • Niasin (B3) is a co -enzyme in various chemical reactions • The body can form niacin from the amino acid Tryptophan • Deficiency: Pellagra • Food: Niacin can be found in various food items. Protein rich food is favorable due to its content of Tryptophan. • Biotin is a co -enzyme in chemical reactions, it plays role in a build up and brake down of various substance in the body. • Deficiency: is rare, the need is very little. Symptoms are known as hair loss, skin swelling, scale formation etc. • Food: is found in various food items Aulani " Biokimia" Presentation 10

9. Vitamin B • Pantothenic acid is a part of co-enzyme A (energy metabolism) as well as it plays and important role in development of many substances. • Deficiency: is rare • Food: Is found in various food items such as meat, fish, whole corn and beans • Vitamin B6 is a co enzyme in energy metabolism such as during formation of a.a. and f.a., trp. becomes niacin or serotonin, and formation of RBC • Deficiency: lack of energy, irritation, insomnia, anemia etc. • Toxicity: Can cause irreversible nerve damage • Food: Meat, fish, potatoes, rise, bananas etc Aulani " Biokimia" Presentation 10

10. Folate: is a co -enzyme in chemical reactions, important for formation of DNA, activation of vitamin B12 etc. • Note! Important for the development of the fetus during the first semester • Deficiency: Slower formation and proliferation of the cell • Food: Beans and vegetables, mainly green leafy vegetables • Vitamin B12 – Important for the activation of folate in the body and for the maintenance of the myelin sheets • Is absorbed with help of “intrinsic factor” • Deficiency: anemia due to folate deficiency, nerve damage • Food: Almost only found in meat, fish, milk and milk based products as well as eggs. Aulani " Biokimia" Presentation 10

11. Interplay of various food • Vitamin B in Food • Meat products: B1, niacin, B6 and B12 • Milk products: B2 and B12 • Fruit and vegetables: Folic acid • Corn products: B1, B2 and niacin Aulani " Biokimia" Presentation 10

12. Vitamin C • Antioxidant (oxidation-reduction reactions) • Plays a role in the formation of collagen and is important for strong tissues • Plays a role in the respiratory chain • Stimulates absorption on “non-heme” iron in the intestine during the same meal (Fe3+ becomes Fe2+) • Deficiency: bleeding in the palatal, bruises and some other symptoms of scurvy. • Food: fruits and vegetables, mostly citrus fruits. Aulani " Biokimia" Presentation 10

13. Antioxidants • Antioxidants are substances that protect from other substances such as free radicals. Free radicals can stimulate destructive chain reaction for vulnerable substances, that loses their function an become free radicals themselves. It is thought that destructions in cells due to free radicals can speed up the ageing as well as play a role in the development of cancer. Aulani " Biokimia" Presentation 10

14. thank you Aulani " Biokimia" Presentation 10