Does non-equilibrium thermodynamics govern metabolic network expression in microbial communities

1. Does non-equilibrium thermodynamics govern metabolic network expression in microbial communities?

2. Why Thermodynamics? To be sure, we need to know such detailed information, but it is likely to be case specific. There may be few general rules that applied to food webs that are of critical importance. Kinetic models of questionable applicability Huge number of parameters Is there a better approach To be sure, we need to know such detailed information, but it is likely to be case specific. There may be few general rules that applied to food webs that are of critical importance. Kinetic models of questionable applicability Huge number of parameters Is there a better approach

3. Kinetics Example

4. Overview

5. Focus

6. Goal-Based Ecosystem Descriptors

7. Why are these theories not used?

8. Maximum Entropy Production (MEP)

9. MEP: Theoretical Basis

10. Implications of MEP Might mention things about trophic cascades.Might mention things about trophic cascades.

11. Chemical Potential Exploitation

12. Example of MEP and Food Webs

13. Conventional Compartment Model

14. Methanotroph Growth, No grazers

15. Methanotroph Growth, With grazers

16. MEP: methanotroph grazer ratio

17. Basic Cycling Premise

18. Top-down or bottom-up?

19. Microbially-coupled Systems

20. Biogeochemistry and Redox Reactions

21. Ecosystem Metabolic Network

22. Modeling Overview

23. Example: Methanotroph Metabolic Network

24. Methanotroph Reactions

25. Methanotroph Thermodynamics

26. Calculus of Variation (optimal control)

27. Example Output (feasible, non optimal)

28. Biological Structure & Rxn Rates

29. Optimization Time Horizon?

30. Methanotroph Community Experiment

31. Methanotroph Microcosms: 8 Jan 06 (Day 93)

32. After 46 Days

33. Microcosm On-Line Data

34. Off-line Data

35. Dissolved Organic C and TDN

36. Experimental Objectives

37. Summary

38. Acknowledgements