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IAPP boosts islet macrophage IL-1 in type 2 diabetes : Nature ...nature

Explore the simplistic & inflammatory effects of insulin resistance on B-cell function in diabetes, with a focus on IAPP & islet macrophages. Discover potential biological interventions for autoimmune diabetes and how novel diagnostic and therapeutic approaches can target insulitis effectively. Learn about treatment implications for inflammation and metabolic derangement associated with insulin resistance, including microbiome-related factors. Dive into the impact of central and peripheral insulin resistance on fat, liver, and muscle health.

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IAPP boosts islet macrophage IL-1 in type 2 diabetes : Nature ...nature

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  1. Simplistic Inflammatory and Non-Inflammatory Effects of Insulin Resistance on B-Cell Function IAPP boosts islet macrophage IL-1 in type 2 diabetes : Nature ...www.nature.com

  2. Inflammation in IR

  3. Pathogenesis and biological interventions in T1DM- LIKE autoimmune diabetes- Insulitis The class I MHC molecules are hyperexpressed on the β-cell surface in T1D patients making β-cells more susceptible to cytotoxic lymphocyte (CTL)-mediated destruction. Novel diagnostic and therapeutic approaches for autoimmune diabetes — A prime time to treat insulitis as a disease http://dx.doi.org/10.1016/j.clim.2014.11.007 Clinical Immunology, 2014 Juha Grönholm , Michael J. Lenardo

  4. Treatment IR induced Inflammation

  5. Implications for Therapy • Treat Central Mechanisms IR • Treat Peripheral IR- fat, liver, muscle • Treat Inflammation • Treat Biome

  6. Metabolic Derangement, and Insulin Resistance Associated with Microbiome Lipopolysaccharides LPS Fasting-induced adipocyte factor Pioglitazone Treats Secondary Adverse Effects of Abnormal Biome

  7. Probiotic, Prebiotic and Antibiotic Treatment of Abnormal Gut Biome

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