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C-Reactive Protein, Metabolic Syndrome, and Risk for CV Events: Women’s Health Study

C-Reactive Protein, Metabolic Syndrome, and Risk for CV Events: Women’s Health Study. 14,719 women aged  45 years with no history of CVD, cancer, or diabetes and not using HRT at baseline Metabolic syndrome criteria definitions: Obesity: BMI >26.7 kg/m 2

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C-Reactive Protein, Metabolic Syndrome, and Risk for CV Events: Women’s Health Study

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  1. C-Reactive Protein, Metabolic Syndrome, and Risk for CV Events: Women’s Health Study • 14,719 women aged 45 years with no history of CVD, cancer, or diabetes and not using HRT at baseline • Metabolic syndrome criteria definitions: • Obesity: BMI >26.7 kg/m2 • Hypertriglyceridemia: TG 150 mg/dl • Low HDL-C: <50 mg/dl • Hypertension:135/85 mm Hg • Impaired fasting glucose: diagnosis of incident type 2 diabetes during follow-up • Elevated CRP defined as >3 mg/L • Follow-up for cardiovascular events: 8 years Ridker PM et al. Circulation 2003;107:391–397.

  2. CRP Values by Each Component of Metabolic Syndrome: WHS Ridker PM et al. Circulation 2003;107:391–397.

  3. 0 1 2 3 4 5 Distribution of CRP Levels by Number of Components of the Metabolic Syndrome: WHS n=170 p-trend <.0001 n=1135 5.75 n=2292 C-Reactive Protein (mg/L) n=3152 3.88 3.01 n=3884 1.93 n=4086 1.09 0.68 Number of Components of the Metabolic Syndrome Box plots denote median and 25th and 75th percentile CRP values Ridker PM et al. Circulation 2003;107:391–397.

  4. 0 2 4 6 8 Years of Follow-up CVD Event–Free Survival by Metabolic Syndrome Status or CRP: WHS Metabolic Syndrome No CRP <3 mg/L CVD Event-Free Survival Probability CRP >3 mg/L Metabolic Syndrome Yes Ridker PM et al. Circulation 2003;107:391–397.

  5. 0 0 0 2 2 2 4 4 4 6 6 6 8 8 8 CVD Event–Free Survival Stratified by Both Metabolic Syndrome Status and CRP: WHS Total Cohort(N=14,719) LDL <160 mg/dL(N=12,453) LDL <130 mg/dL(N=8,500) CVD Event-Free Survival Probability Years of Follow-up CRP <3 mg/L, No Metabolic SyndromeCRP 3 mg/L, No Metabolic Syndrome CRP <3 mg/L, Metabolic SyndromeCRP 3 mg/L, Metabolic Syndrome Ridker PM et al. Circulation 2003;107:391–397.

  6. Relative Risk for CV Event by Metabolic Syndrome Status and CRP Level: WHS Ridker PM et al. Circulation 2003;107:391–397.

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