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Back to Basics for Surgery Neurosurgery. R. Moulton. Principles of Neurological Diagnosis. Questions. What is the lesion Where is the lesion. History Physical (Neurological) Examination Special Tests. Presentation of Neurosurgical Illness. Raised ICP Headache, vomiting papilloedema
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Back to Basics for SurgeryNeurosurgery R. Moulton
Questions • What is the lesion • Where is the lesion
History • Physical (Neurological) Examination • Special Tests
Presentation of Neurosurgical Illness • Raised ICP • Headache, vomiting • papilloedema • Neurological Dysfunction • General – level of consciousness • Focal – sensory or motor loss • Seizures • Pain
What is the lesion – history • Where is the lesion – neurological exam
History (What is the lesion?) • Symptoms • Mode of onset • Speed of onset • Prior relevant illness • Progression/regression of symptoms
Neurological Examination (Where is the Lesion?) • Level of Consciousness – GCS • Mental status – orientation, memory, concentration, abstraction, calculation • Cranial Nerves • Motor examination • Upper vs. lower motor neuron • Cerebellar function • Gait • Sensory examination • light touch, pain & temp, joint position sense • Cortical sensory modalities
Cranial Nerves • I Olfactory • II Optic • III Oculomotor • IV Trochlear • V Trigeminal • VI Abducens • VII Facial • VIII Acoustic • IX Glossopharyngeal • X Vagus • XI Accessory • XII Hypoglossal
Motor Examination • Upper Motor Neuron • Weakness (distal > proximal) antigravity muscles preserved • Increased reflexes and tone (spasticity) • Disuse atrophy • Loss of coordination (ataxia) • Apraxia • Upgoing plantar response
Lower Motor Neuron • Weakness • Decreased tone • Decreased reflexes • Denervation atrophy • Coordination usually intact
Sensory Examination • Special senses – cranial nerves • Basic Modalities • Light touch, pain & temp, vibration & proprioception • Dermatomes, peripheral nerve distribution • Cortical Modalities • Graphaesthesia, stereognosis, simultaneous appreciation of tactile stimuli, somatotopognosis, agnosagnosia, neglect
Special Tests • Biochemical, hematological, microbiology • Blood • CSF • Imaging • Plain x-rays • CT • MRI • Angiography • Electrophysiology • EMG, nerve conduction, EEG etc.
Neurological Examination of the Comatose Patient • Level of Consciousness • Glasgow Coma Score • Brainstem Integrity • Pupillary Reaction • Ocular Movement • Corneal reflexes • Gag/breathing
Eye Opening spontaneous 4 to voice 3 to pain 2 none 1 • Verbal Response oriented 5 confused - sentences 4 words only 3 sounds 2 none 1 • Movement obeys 6 localises 5 flexion withdrawal 4 abnormal flexion 3 extension 2 none 1
Rostral-Caudal Deterioration • Midbrain • Bilateral pupillary abnormalities • Oculomotor abnormalities • Pons • Loss of corneal reflexes • Medulla • Loss of gag reflexes • Respiratory and vasomotor collapse
Brain Tumour Classification • Intra-axial (frequently malignant) • Primary • Glial • Choroid plexus • Neuronal or mixed glial-neuronal • PNET/medulloblastoma • CNS lymphoma • Pineal region • hemangioblastoma • Metastatic
Brain Tumour Classification • Extra-axial (usually benign) • Meninges • Cranial nerves (Schwannoma) • Pituitary • skull
Glial Tumours • Astrocytoma (gliobastoma multiforme) • Oligodendroglioma • Ependymoma • Mixed tumours • Gr. I - IV
Treatment • Supportive • Specific • Corticosteroids (dexamethasone) • Surgical • Biopsy • Excision • Internal decompression
Treatment contd. • Radiotherapy • Conventional • Stereotactic focused • Chemotherapy • Temazolamide (malignant glial tumours) • Lymphoma protocols • Specific to tissue of origin for metastases • Observation
No Contrast With Contrast
Stroke Definition • Sudden onset of a neurological deficit due to disease or injury of the blood supply of the brain.
Stroke Classification • Ischemic • Bland • Hemorrhagic transformation • Hemorrhagic (hemorrhage is 10 event) • Hypertension • Amyloid angiopathy • Aneurysmal • AVM • Other
Ischemic Stroke (Infarction) • Thrombotic (local vessel disease) • Embolic • Artery to artery (usually carotid) • Heart to artery (atrial fibrillation) • Paradoxical (vein to artery) • Other (air, foreign body, iatrogenic)
Intracerebral Hemorrhage • Hypertensive • Occurs in long narrow perforating arteries (basal ganglia, thalamus, pons, cerebellar nuclei) • Charcot-Bouchard aneurysms • Related primarily to duration of hypertension
Intracerebral Hemorrhage • Amyloid angiopathy • Age related change in cerebral vessels • Lobar hemorrhage • Most commonly in posterior part of cerebral hemispheres
Intracerebral Hemorrhage • AVM • Berry aneurysm • Subarachnoid hemorrhage • Usually exclusively subarachnoid • May have intracerebral component • Occasionally exclusively intracerebral
Management • Diagnosis • History • Physical Examination • Special tests (imaging) • Treatment
Stroke Diagnosis • History • Rapid onset fixed deficit – ischemic • Rapid onset progressive deficit – hemorrhage • Sudden severe headache, nausea/vomiting/photophobia +/- neurological deficit - SAH
Stroke Physical Examination • Focal deficits • Most often ischemic stroke or ICH • Much less common in SAH • Alteration in level of consciousness • SAH • ICH • Delayed swelling from large infarcts
Stroke Investigation • CT scan • First line imaging to distinguish infarct from hemorrhage • 1st choice for confirming SAH, LP if negative • Other • Cerebral angiography, doppler for carotids • MRI in special circumstances
Acute Stroke Treatment • Supportive • Airway • Blood pressure • Definitive • Thrombolysis • Hematoma evacuation (limited circumstances)
Prevention Risk factor modification Hypertension, smoking, diabetes, lipids/cholesterol Antiplatelet agents (artery-artery embolism, local occlusive disease) Anticoagulation (heart to artery emboli) Surgical prevention Carotid endarterectomy, stenting Aneurysm obliteration AVM excision Stroke Treatment