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Pyrimidinsynthese

Pyrimidinsynthese. ATP. O. + NH 3. C. CH 2. CH 2. COO -. H 2 N. C. C. HO. O. O. O. H. CH 2. + NH 3. C. P. CH 2. - OOC. CH 2. CH 2. COO -. C. C. H. O. O. +. O. H. O. H 3 N. C. C. H. P. O. O. O. C. O. O. + NH 3. - OOC. CH 2. COO -. C. H.

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Pyrimidinsynthese

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  1. Pyrimidinsynthese

  2. ATP O +NH3 C CH2 CH2 COO- H2N C C HO O O O H CH2 +NH3 C P CH2 -OOC CH2 CH2 COO- C C H O O + O H O H3N C C H P O O O C O O +NH3 -OOC CH2 COO- C H W. Storch, D. Doenecke Glutamin Glutamat HO H2N O + H3N C HO O O ADP ADP Carbamoyl phosphat Carbamoylsäure Carboxyphosphat Bicarbonat Aspartat

  3. Q O H2O P O N O O QH2 H2N P C HO O HO N O O C H O O C HO H2 H CH2 CH C H + H3N O C Carbamoylaspartat Dihydroorotat Orotat O

  4. ATP H+ O C O O O O O P P P P P P O O O HO OH O C O C O O O O O O HO OH P P CO2 O O OH O O H N C C O CH C N H H Orotat OMP UMP UDP UTP 5-Phosphoribosyl-1-pyrophosphat (PRPP) ADP ADP

  5. ATP +NH3 +NH3 P P P P P P C -OOC CH2 CH2 COO- H2N C C CH2 CH2 COO- H H O O N C H C O CH O O C C C N O O H N C H O O HO HO OH OH C O CH P UTP O O C N H Glutamin Glutamat H2N O ADP UTP CTP

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