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Thursday, October 13, 2011 Seminar Room of the Institute of Cell and Molecular Pathology

Cluster of Excellence - “From Regenerative Biology to Reconstructive Therapy”. Lunch Seminar Guest:.

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Thursday, October 13, 2011 Seminar Room of the Institute of Cell and Molecular Pathology

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  1. Cluster of Excellence - “From Regenerative Biology to Reconstructive Therapy” Lunch Seminar Guest: Sabine Mai, BSc, MSc, PhDDirector The Genomic Centre for Cancer Research and Diagnosis (GCCRD) University of Manitoba, Winnipeg, Canada„Nuclear architecture, genomic instability and cancer “ Thursday, October 13, 2011 Seminar Room of the Institute of Cell and Molecular Pathology Theoretische Institute II (Bldg. I6) Level 01, Room 2013, 1:00 pm (c.t.) To arrange an appointment with the guest, please contact: Secretarial Office - Prof. Dr. B. Schlegelberger, Tel. 0511 532-4523

  2. The Genomic Centre for Cancer Research and Diagnosis (GCCRD) was created as a Regional/National Facility for all cutting edge imaging applications.  The GCCRD is part of the Manitoba Institute of Cell Biology (MICB), CancerCare Manitoba, and the University of Manitoba, in Winnipeg, Manitoba, Canada.  It began with research into genomic instability and mechanisms of neoplasia, but has since expanded to meet differing project needs.  Activities of the GCCRD now include projects in molecular biology, cell biology, histopathology, and genetic diseases.  The goals of the GCCRD are basic and translational research, as well as the education of students and highly qualified personnel in genomic instability, cancer genetics and imaging.  The GCCRD was initiated by Dr. Sabine Mai.  The facility was established through funds from the Canada Foundation for Innovation in 1999, and it has since been fully supported by CancerCare Manitoba. The GCCRD is equipped with state-of-the-art equipment, including the super resolution microscope (ELyra), and its technical capabilities are diverse, but complementary.

  3. Recent publications: Knecht H, Mai S. 3D imaging of telomeres and nuclear architecture: an emerging tool of 3D nano-morphology based diagnosis. J Cell Physiol.2011 226:859-67. Klewes L, Höbsch C, Katzir N, Rourke D, Garini Y, Mai S. Novel automated three-dimensional genome scanning based on the nuclear architecture of telomeres. Cytometry A. 2011 79:159-66. Scaltriti M, Eichhorn PJ, Cortés J, Prudkin L, Aura C, Jiménez J, Chandarlapaty S, Serra V, Prat A, Ibrahim YH, Guzmán M, Gili M, Rodríguez O, Rodríguez S, Pérez J, Green SR, Mai S, Rosen N, Hudis C, Baselga J. Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2+ breast cancer patients. Proc Natl Acad Sci U S A. 2011 108:3761-6. Knecht H, Brüderlein S, Wegener S, Lichtensztejn D, Lichtensztejn Z, Möller P andMai S. 3D nuclear organization oftelomeres in the Hodgkin cell lines U-HO1 and U-HO1-PTPN1: PTPN1 expression prevents the formation of very short telomeres including  "t-stumps". BMC Cell Biology. 2010 11:99 . Guffei A, Sarkar R, Klewes R, Righolt C, Knecht H,Mai S. Dynamic chromosomal rearrangements in Hodgkin's lymphoma are due to ongoing 3D nuclear remodeling and breakage-bridge-fusions. Haematologica. 2010 95:2038-46. Silva AG, Graves HA, Guffei A, Ricca TI, Mortara RA, Jasiulionis MG, Mai S. Telomere-centromere-driven genomic instability contributes to karyotype evolution in a mouse model of melanoma. Neoplasia. 2010 12:11-9.

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