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Thrombopoietin

Thrombopoietin. By: Kate League. Basics. Produced by the Liver and Kidney “Target Cell”: Bone Marrow Regulates platelet production (constant ) Stimulates precursor cells in the bone marrow to differentiate into megakaryocytes  generate platelets (essential to blood clotting)

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Thrombopoietin

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  1. Thrombopoietin By: Kate League

  2. Basics • Produced by the Liver and Kidney • “Target Cell”: Bone Marrow • Regulates platelet production (constant) • Stimulates precursor cells in the bone marrow to differentiate into megakaryocytes  generate platelets (essential to blood clotting) • No specific time in your life when more active • Under homeostatic control

  3. Protein (332)

  4. TPO & Platelets • Circulating platelets, megakaryocytes, and precursors are covered with receptors for TPO. • Counts are high=most TPO bound to platelets • Counts are low=most TPO bound to megakaryocytes to replenish platelet supply • 1011 platelets made each day (No replacement besides blood transfusion.)

  5. Normal: 150,000-400,000 platelets per microliter (mcL) Red-Blood Cells Platelets

  6. Too Much and Too Little Thrombocytopenia (lower-than-normal # of platelets) Causes? -cancer chemotherapy -certain medications -hemolytic anemia -hypersplenism -idiopathic thrombocytopenic purura -leukemia -large blood transfusion -celiac disease -vitamin K deficiency Thrombocytosis (higher-than-normal # of platelets) Causes? -anemia -chronic myelogenous leukemia -primary thrombocythemia -spleen removal A common fix is to undergo a transfusion. Plus each cause can make the treatment different.

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