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Bring back lost lover No more debt

Bring back lost lover No more debt. Pass DA first time. The effects of herbal medicine in relation to anaesthesia. It's natural, it's harmless. Problems with herbal meds. Disclosure of use to healthcare practitioner Pharmacokinetics and pharmacodynamics Systemic toxicity

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Bring back lost lover No more debt

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  1. Bring back lost lover No more debt Pass DA first time

  2. The effects of herbal medicine in relation to anaesthesia

  3. It's natural, it's harmless

  4. Problems with herbal meds • Disclosure of use to healthcare practitioner • Pharmacokinetics and pharmacodynamics • Systemic toxicity • Multiple adverse effects • Manufacturing standards

  5. Systemic effects of herbal meds • CVS • CNS • LIVER • Immune system • Endocrine

  6. Aloe Vera Oral laxative Topical cream

  7. Inhibition of GPIIb/IIIa receptors on platelet Inhibition of GPIa interaction with inter-canalicular system Inhibition of von Willebrand – platelet – fibrinogen interaction Poor platelet plug formation increased risk of haemorrhage

  8. Chamomile Restlessness, insomnia Gastrointestinal upset

  9. Central nervous system suppressant Increased risk of bleeding

  10. Echinacea URTI Wound healing

  11. Decreases immunosuppressive effects Additive hepatotoxic effects Inhibits CYP3A4

  12. Evening primrose PMS, Menopause, Atopic eczema Rheumatoid arthritis, Multiple sclerosis

  13. Decreases anticonvulsants Augments anticoagulants Increases risk of seizures under anaesthetic Seizures if Concomitant use with phenothiazines

  14. Feverfew Migraine, toothache Fever, arthritis

  15. Anticoagulants, antiplatelet agents, and NSAIDs – inhibition of platelet aggregation and risk of bleeding

  16. Garlic Hypertension, hyperlipidaemia, IHD, Bacterial infections, Vampires

  17. Protease inhibitors NNRTI Cyclosporin Anti-coagulant

  18. Ephedra (Ma Haung) Appetite suppressant Weight loss

  19. Side effects • palpitations, • hypertension, • tachycardia, • stroke, • seizures • Cardiomegaly • Catecholamine depletion • Fatal arrhythmias

  20. Ginger Nausea Arthritis

  21. Increase stomache acid Anti-platelet Enhanced sedative effect of BZD Affects anti-HT meds Alters cardiac contractility Hypoglycaemia

  22. Ginkgo Memory loss, Alzheimer's PVD, frostbite

  23. Thiazide diuretics increased risk of bleeding Buspirone and fluoxetine Trazodone – associated with coma Insulin – altered insulin secretion Anticonvulsants – decreased efficacy Mild inhibitor of CYP3A

  24. Ginseng Bring back lost lover Increase stamina

  25. Digoxin – increased effects Anticoagulants – decreased efficacy Monoamine oxidase inhibitors – insomnia, headache, tremor, agitation, and worsening of depression Diabetes medications – increased risk of hypoglycaemia Opioids – decreased analgesic effect Oestrogen – additive estrogenic effect

  26. Kava Anxiety, insomnia

  27. Augments BZD • Inhibits levodopa • CNS Depressant • Antihistamine • Alcohol • Hepatotoxic

  28. Liquorice Ulcers, gastritis, arthritis

  29. Prolongs effect of corticosteroids Increases digoxin toxicity Enhances K+ depleting diuretics Hypertension

  30. St. John's wort Depression, anxiety Mood disorders

  31. Cyclosporine – decreased levels and possible transplant rejection Digoxin – decreased levels Protease inhibitors – decreased levels Tacrolimus – decreased levels Methadone – decreased serum concentration Antidepressants – Serotonin-syndrome Oral contraceptives – decreased levels Theophylline – decreased levels Warfarin – decreased INR 5-hydroxytryptamine 1 agonists – serotonin syndrome. Potentially induce CYP3A4, CYP2D6 and CYP1A2

  32. Valerian Insomnia, anxiety Restlessness, tension

  33. CNS Depression CYP3A4 inhibition

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