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Comprehensive Study of Embryology: Development, Genetics, and Clinical Applications

Explore the diverse aspects of embryology, from gametogenesis to organogenesis, using reputable textbooks and online resources. Understand the stages of development, genetic applications, and clinical implications in human and animal embryology. Topics also cover stem cells, genetic modification, and current ethical debates.

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Comprehensive Study of Embryology: Development, Genetics, and Clinical Applications

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  1. 胚胎學 陳建榮 http://web.nchu.edu.tw/pweb/users/chenjr/

  2. 教科書及參考資料： 1. The Developing Human (9TH, 2013, by Keith L. Moore & T. V. N. Persaud) 2. Langman’s medical embryology (12th, 2012, by T.W. Sadler) 3. Veterinary embryology (2006, by McGeady et al.) 4. Domestic animal embryology (2010, by Hyttel et al.) 5. http://embryology.med.unsw.edu.au/ 6. 講義 評量方式： 期中考 (45%) 期末考 (45%) 平時成積 (10%)

  3. Topics • 配子的形成與受精 • 受精卵的著床與胚胎成形 • 各系統的正常或異常發育與臨床疾病的關係 • 畸胎學

  4. Embryology • Animal development is a continuous process that begins when a zygote is formed • Development does not stop at birth

  5. Developmental Periods • Gametogenesis • Spermatogenesis • Oogenesis • Prenatal period (Fertilization) • Embryo: Zygote • Cleavage • Implantation • Gastrulation… • Organogenesis • Fetus • Postnatal period • Neonate (<1 month) • Infancy (< 1 yr) • Childhood • Puberty (13 yr – 16 yr) • Adulthood

  6. LNMP (last normal menstrual period) 胎齡: fetus embryo Trimester

  7. Carnegie stagesare a system used by embryologists to describe the apparent maturity of embryos 1st trimester

  8. 1st week

  9. Formation of Bilaminar Embryonic Disc Stage 5: 7th –12th day full implantation 2nd week

  10. Stages 6-9: Day 13-21 Somites 3rd week

  11. Stages 10-17 4th to 6th week

  12. 7 8 • Embryo(end of the 8th week) - all major structures are present • Fetus(after 8th week)

  13. Genetics and Molecular biology are applied in human development • Ian Wilmut [1997] Somatic cell nuclear transfer – Dolly lamb • Embryonic stem cell

  14. Somatic cell nuclear transfer 桃莉羊與Ian Wilmut教授

  15. 複製動物的肉和乳品安全嗎？ 基因改良食品的安全性？

  16. 複製人類是否無可避免？聯合國管理下的未來選擇

  17. Stem cell Embryonic stem cell Morula Blastocyt 組織修補 \器官替換 人造器官(心臟、肺、支氣管…)

  18. 「救命寶寶」（rescue baby） 胚胎著床前基因診斷

  19. 全球首例 英允許「一父二母」基改寶寶 • Dysfunctional mitochondria: • Diabetes mellitus and deafness (DAD) • Visual loss • Seizures • Dementia …

  20. Anatomical position

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