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ANTICHOLINESTERASES

ANTICHOLINESTERASES. CLASSIFICATION. A. Centrally Acting (Used for the treatment of alzeimer’s disease) B. Peripherially Acting Reversible Irreversible. MECHANISM OF ACTION. Acetylcholine Alcohols Carbamates Organophosphates Aging. NEOSTIGMINE. STRUCTURE MODE OF ACTION P.K

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ANTICHOLINESTERASES

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  1. ANTICHOLINESTERASES

  2. CLASSIFICATION • A. Centrally Acting (Used for the treatment of alzeimer’s disease) • B. Peripherially Acting Reversible Irreversible

  3. MECHANISM OF ACTION • Acetylcholine • Alcohols • Carbamates • Organophosphates • Aging

  4. NEOSTIGMINE • STRUCTURE • MODE OF ACTION • P.K • PHARMACOLOGICAL ACTIONS • Skeletal muscles • Eye • G.I.T • Urinary bladder

  5. Exocrine glands • Lungs • C.V.S • C.N.S THERAPEUTIC USES • Abd distension/paralytic ilius • Urinary retension • Myasthenia gravis

  6. Drugs contraindicated in myasthenia gravis 4. Post operative use 5. Reversal of neuromuscular blocking effect 6. Treatment of glaucoma .Myasthenic crises versus cholinergic crises .Tensilon test

  7. Adverse effects • Physostigmine • Pyridostigmine • Edrophonium • Echothiophate

  8. Irreversible anticholinesterases • Organophosphate poisoning and its management Causes Manifestations Management . General measures . Specific measures (Mx of convulsions, cholinergiicmuscrinic effects and enzyme inhibition)

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