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Technology Transfer from University of Oxford

Explore the technology transfer activities of Isis Innovation, a company owned by the University of Oxford, including patenting, licensing, formation of new companies, consulting, and research material sales.

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Technology Transfer from University of Oxford

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  1. Technology Transfer from the University of OxfordDr Sarah Macnaughton, February 6th 2007

  2. Isis Innovation • A company owned by the University of Oxford • To help those researchers who wish to commercialise the results of their research Activities • Patenting • Licensing of intellectual property • Formation of new companies • Consulting and service contracts – Oxford University Consulting • Research Material Sales • Oxford Innovation Society • Managing Seed Funds • Technology Transfer consulting – Isis Enterprise

  3. Research at Oxford • 4,000 researchers • 6,400 doctoral students • Most Powerful UK Research University • Research Fortnight • Most Innovative UK University • Cross Atlantic Capital Competition • Highest Research Spend in UK • £303 million (2005/2006)

  4. Industry (UK & Overseas) £25m Overseas Public/Charity & Other £14m Research Funding 2005-2006 £303million [1993 £83m] UK Charity £75m UK Govt/NHS £18m Research Councils £71m European Commission £10m Total £213m + HEFCE £90m

  5. Reporting Structure (partial) UNIVERSITY COUNCIL Intellectual Property Advisory Group Four Academic Divisions Medical Sciences Division Maths, Physical & Life Sciences Division Humanities Division Social Sciences Division Biochemistry Clinical Medicine Physiological Sciences Psychology ChemistryComputer Science Earth SciencesEngineering Science Materials Mathematics Physics Plant Sciences Statistics Zoology Anthropology Archaeology Area Studies Development Studies Economics Educational Studies Environment Internet Institute Law Saïd Business SchoolPolitics Social Policy and Social WorkSociology Chinese Studies Classics Comparative Philology Ruskin School of Drawing English Language & LiteratureHistory Medieval & Modern LanguagesModern Middle Eastern Studies Music Oriental StudiesPhilosophyTheology Administration Regional Liaison Research Services Begbroke Science Park Isis Innovation Limited Science Enterprise Centre

  6. Physical Science Group (9) Administration (10) Life Science Group (9) Head of Group Dr David Baghurst Project Managers Dr David Churchman Dr David Eastham Dr Jamie Ferguson Dr Mairi Gibbs Dr Tony Lewis Terry Pollard Dr Roger Welch Administrator Anna Pickvance Deputy Chairman Dr Tim Cook Managing Director Tom Hockaday Portfolio Manager James Mallinson Lawyer Stephen Brett Emma Wheatley Office Manager Jenny Bailey Marketing Cynthia Warmington Accounts Gemma Allnutt Facilities Jane Tarry Reception Gillian Hicks Head of Group Linda Naylor Project Managers Dr Fiona Begg Dr Dina Chen Dr Sarah Deakin Dr Colin Story Dr Adam Stoten Dr Weng Sie Wong Dr Suzy Wood Patent & Licence Administration Manager Steven Bayliss Isis Innovation Contacts Business Innovation & Consulting (6) Head of Group Catherine Quinn Project Managers Andrew Goff Gill Rowe Dr Elen Wade-Martins tba Administrator Kerry Antcliffe Isis Enterprise (3) Dr Mark Mawhinney Dr Sarah Macnaughton Alicia Martinez

  7. Isis Innovation 1997 - 2006 Y/E Mar 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 University investment £m pa £0.04 £0.3 £0.5 £1.0 £1.0 £1.0 £1.0 £1.0 £1.2 £1.2 Staff 3 9 9 17 21 23 34 36 36 35 Projects 168 243 319 415 476 629 725 764 784 Patents filed 31 51 55 63 82 65 52 55 57 Licence 4 8 18 21 36 42 37 31 38 45 Consultancy 34 50 48 59 Spin-outs 1 2 3 6 8 8 7 3 4 6 OGTOpsys Prolysis Oxxon Mindweavers Ox Ancestors Zyentia ReOx OMD Ox. Nanolab Synaptica Celoxica Dash BioSensors Novarc Oxitec Riotech G-Nostics RF Sensors Avidex Oxonica Biosignals Ox ArchDigital Immunote OCSI Surface T Oxbr. Pulsars AuC TolerRx NaturalMotion ORRA EKB Celleron OMIA OXIVA Inhibox Glycoform Ox. Catalysts ThirdPhase PharmaDM Pharminox BioAnalab TDeltaS OxLoc Minervation VASTox Ox Bee Co Spinox

  8. Intellectual Property Policy (October 2000) • University claims ownership of all employees’ and students’ IP rights resulting from University research activities • The university assists those researchers who wish to commercialise their research • by patenting, licences, spinout companies & consultancy • Researchers share the benefits • Royalty shares from licences • Equity in spinout companies • Income from personal consultancy

  9. Assignment of intellectual property rights Inside the University Outside the University Researchfundingsource Spin-outs Government Research Services 40 Staff 85% Graduates 33% Post grad degrees IP Due Diligence Team Isis Innovation 36 staff 75% Graduates 50% Science doctorates Consulting Charities Licences Industry New sponsored research Transfer of Intellectual Property

  10. Total net Researchers University Department Isis revenue personally General Fund Funds Innovation to £72k 61% 9% 0% 30% to £720k 31.5% 21% 17.5% 30% over £720k 15.75% 28% 26.25% 30% Licensing • Options or licences signed on 200 projects • Some will generate over £1m in royalties • Benefits to licensee, researcher & University • E.g. Hymatic Satellite cooler projected benefits £6m between 2001-2006 Royalties • Patent budget £1.2m per annum & royalties • Isis pays patent costs & recovers these from royalties

  11. Oxford University Consulting • Helps researchers market their consultancy & services expertise • Offers access to unique consultancy & departmental services of Oxford University • Problem solving, data analysis • Expert evaluation, due diligence • Specialist scientific facilities • Testing and analysis services • Expert workshops

  12. Material Sales • Isis negotiates Material Sales Agreements (MSA) with companies. • Suitable Materials are those: • Already existing in labs • Often produced in surplus through regular experiments • For example: • antibodies/hybridomas • protein complexes • transgenic models

  13. Market Cap. Equity Main Business 1959 Oxford Instruments £101m* - Scientific Instruments 1977 Oxford Lasers - Lasers 1988 Oxford GlycoSciences £102m* Yes Glycobiology 1989 Oxford Molecular £53m* Yes Drug design 1992 Oxford Asymmetry £316m* Yes Chemistry 1994 PowderJect £542m* Yes Drug delivery 1995 Oxford Gene Technology Yes Gene Chips 1996 Oxford BioMedica £152m* Yes Gene Therapy 1997 Oxagen Yes Genetics Total £1,266m Quoted valuations at April 2006 or at sale of company. * Currently listed on London Stock Exchange/Alternative Investment Market * Previously listed companies Oxford Spin-outs Pre 1997

  14. Oxford Spin-outs Post 1997 (a) 1998 Feb Opsys Displays Mar Synaptica Neurodegeneration Jun Prolysis Antibiotics Nov Celoxica* IT Nov Sense Therapeutic Pharmaceuticals 2000 Jan Third Phase Clinical trials mngt Apr Mindweavers Sensory development May Oxford BioSignals Vigilance monitoring Aug Oxford BioSensors Biosensors Dec TolerRX Immunology Dec OXIVA Medical software Dec PharmaDM Drug design 1999 Mar Avidex Pharmaceuticals Jun Oxxon Pharmaccines Pharmaceuticals Jun Dash Technologies IT Aug Oxonica* Nanotechnology Aug AuC Sensing Sensors Dec Oxford Medical Imaging Image analysis 2001 Mar OxLoc GPS/GSM tracking Mar The Oxford Bee Company Pollination Apr Oxford Ancestors Genealogy Apr Novarc Press tooling May Oxford ArchDigital Digital archaeology Nov NaturalMotion Animation software Dec Inhibox Drug searching

  15. Oxford Spin-outs Post 1997 (b) 2002 Jan Pharminox Cancer Drugs Feb Minervation Health Information Mar Spinox Artificial silk May Zyentia Protein Structures Aug Oxitec Insect pest control Oct Oxford Immunotec TB Diagnostics Nov ORRA Risk Analysis Nov Glycoform Cancer drug dev’t Nov BioAnalab Pharma Testing 2005 May Oxford Nanolabs Biosensors Jun Oxford RF Sensors Industrial Sensors Sep Oxbridge Pulsars Radar/Comms Nov Celleron Cancer Drug Dev’t Dec Oxford Catalysts* Fuel Cells 2006 Mar TDeltaS Metabolism Apr Oxford Medistress Stress Diagnosis Jun Particle Therapeutic Drug delivery Jul Aurox Microscopy Sep Oxford Advanced Surfaces Polymers Oct Cytox Alzheimers Diagnostic Nov OxTox Drug Testing 2003 Feb VASTOx* Pharma screening Jun ReOx Drug discovery Jul Riotech Hepatitis drug dev’t Aug OCSI Social inclusion 2004 Jun OMD Breath Analysis Jun G-Nostics Anti-smoking test Nov Surface Therapeutics Drug development Dec EKB Technology Bioprocess Eng’ring Total external investment to date in spin-outs Post 1997: £282m £30m Seed/Business Angels & £252m Venture/Institution Capital

  16. Spin-out Strategy Research Group Head New ManagingDirector technology interchange moves Senior Scientist Research Director University New Company Support Finance & Admin Scientists Sales & Marketing Production Scientists

  17. Founder Researchers Shareholder, Director, Consultant I N V E S T M E N T Shareholders Isis Project Manager University Nominee Director Shareholder, Director Investor (1) Investor (2) ? Manager (1) Manager (2)? CEO, Shareholder Lawyers Lawyers Advisers Accountants Accountants Bankers Bankers Time Spin-outs – The Players

  18. Investment Sources Proof of Concept Fund £1.8m • Oxford, Cambridge, Imperial, UCL • Pre-commercialisation support Oxford University Challenge Seed Fund £4m • Launched in 1999 University £1m, Treasury, Wellcome & Gatsby £3m • Development projects, spin-out seed equity; in a total of 68 projects • £4m investment has resulted in Equity stakes in 21 spin-outs, 7 completed licensing deals & 33 active technology projects • These 21 spin-outs have attracted £40m seed/venture investment Isis Angels Network • Business Angels • Seed / Venture Capital • Private Equity • 60 Members • Events • No Charges

  19. Isis Enterprise • Consulting expertise and advice in technology transfer • Technology transfer includes the management of intellectual property and its transfer from research to commercialisation • Long term working partnerships • Short term consultancies in technology transfer • Site visits and meetings in Oxford • Review of a university TTO or • Attendance at company meetings • Helping set up an office for technology transfer and/or knowledge transfer • Residence in Isis for client’s staff • www.isis-enterprise.com

  20. Oxford Innovation Society • Established in 1990 to foster University/business links • Since 1990 over 90 companies have joined • Companies pay an annual fee of £6,800 for membership Membership Benefits • Ready access to the academics and University • Advance notification of all marketed patent applications • Invitations to thrice-yearly meetings and dinners • Customised research presentations and seminars • Regular newsletters and portfolios

  21. OIS Meeting & Dinner • Tea & coffee reception • Academic presentation • Sponsor presentation • Champagne reception • Dinner in College • After dinner drinks

  22. Begbroke Science & Business Park OxLoc Prolysis Oxonica Innovation Centre OGT Dept. of Materials • Owned & operated by Oxford University • University research labs • Business Incubator & premises for new companies • Central meeting room and café

  23. Local business & professional environment Culture Change • All three must proceed together but the University must lead the change because.. • The ideas are in the University • If University provides TT resource,change will happen faster • Oxford pre-Isis 1 spin-out every 4 years, post Isis 6 per year • If the University doesn’t lead, the University may not receive its share of the benefits University entrepreneur culture University technology transfer resource

  24. Keys to Success • Strong research base • Well resourced Tech Transfer Organisation • Project Managers with Academic & Industrial credibility • Supportive investors and University Conclusions • Oxford is a prolific source of world class research and has mechanisms for technology transfer • Licensing • Consulting • Spin-out companies

  25. Contacts Isis Innovation Ltd Ewert House Ewert Place Summertown Oxford OX2 7SG T 01865 280830 F 01865 280831 E innovation@isis.ox.ac.uk www.isis-innovation.com Register to receive Isis E-News at www.isis-innovation.com/news/enews

  26. www.isis-innovation.com

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