magnasweet

1. The World’s leading manufacturer of licorice products since 1850 presents the Magnasweet product line www.magnasweet.com

2. Introduction MAFCO Magnasweet products are a line of multifunctional flavor enhancers, sweetness potentiators and masking agents designed to meet the diverse needs of the Pharmaceutical and Personal Care Products Industries. Based on glycyrrhizin, Magnasweet products are formulated to offer maximum benefits at very low concentrations. The Origins of these natural products can be traced back to the unique properties of licorice root, known and used for centuries, due to its medicinal value and flavoring characteristics. Magnasweet products are used in a wide variety of formulations to: • Enhance, intensity and potentiate flavors • Augment, modify and improve product sweetness • Eliminate bitter and unpleasant aftertastes Mafco Worldwide Corporation, recognized as the leading manufacturer of licorice products worldwide, has formulated these products to optimize the beneficial enhancing, sweetening and synergizing qualities of glycyrrhizin. Magnasweet products are composed of GRAS and FDA approved ingredients. When you consider our commitment to customer service, our ability to provide technical assistance, and our international marketing and distribution capabilities, you will find that MAFCO Magnasweet products will not only solve you formulating needs butt will also satisfy the most complete demands of your business.

3. Pharmaceutical Applications • Introduction Magnasweet products have been developed to maximize the unique qualities of Monoammonium Glycyrrhizinate (MAG). This compound, recognized by the FDA as GRAS, is the primary flavoring constituent of the Magnasweet products line. Designed to satisfy a wide variety of formulation needs, Magnasweet products provide varying degrees of flavor enhancement, masking ability, and sweetness magnification. II. Benefits The benefits derived from the use of Magnasweet products in pharmaceutical formulations include the following: • Effectively masks bitter, harsh and astringent aftertastes common to pharmaceutical active ingredients • Enhances and magnifies natural and artificial flavors • Potentiates, modifies and improves the sweetness character of artificial sweetener systems • Highly compatible and stable in a wide range of preparations and dosage forms • Intensive character allows for significant flavor modification at very low levels of use

4. Pharmaceutical Applications • Flavor Characteristics Magnasweet products have a characteristic sweetness that can be described as intense and lingering. These products work synergistically with other natural and artificial sweeteners to provide a better overall sweetness, and in proper combination can be used to crate systems that simulate sucrose. Sweetness, flavor, and mouth feel can all be significantly improved when added at optimum levels. As illustrated in the graph, the delayed onset and prolonged duration of glycyrrhizin’s sweetness make it particularly well suited to correcting flavor problems commonly described as aftertastes. These would include background bitterness, acidity and off flavor. By selecting sweeteners of varying intensity, onset, and duration, in conjunction with Magnasweet products, significant improvements in flavor perception can be achieved. IV. Product Line Presolubilized Forms: MAFCO Magnasweet in shelf stable solutions of glycerin or propylene glycol. Designed for use where rapid dispersion is desired or where processing restricts the use of powders. Powder Forms: MAFCO Magnasweet in dry powered form with good dispersion and compression properties. Designed for dry mixes, aqueous systems and tableting.

5. Pharmaceutical Applications V. Solubility Generally, Magnasweet products are soluble in most solvents at their effective use levels. Theses products are designed for rapid incorporation into a variety of formulations included aqueous, alcoholic and hydro-alcoholic types. They can also be readily formulated into products containing propylene glycol and glycerin. Successful incorporation can be achieved in oil based systems through the use of a suitable emulsifier. Most favorable solubility can be achieved between pH values of 3.5 to 8.0. Powdered items will most readily dissolve by using moderate agitation and by elevating the temperature of the solvent. Temperatures between 140-160o F are optima. Liquid Magnasweet items should be used when adequate agitation is unavailable or temperatures during mixing are performed under ambient conditions. VI. Stability, Interactions and Handling Magnasweet products are chemically stable under normal storage, processing and packaging conditions. The Magnasweet product line exhibits excellent long term shelf stability in aqueous and alcoholic solutions. Additionally, Magnasweet products have excellent stability and compatibility in conjunction with active ingredients used in pharmaceutical formulation. Storage precautions should be taken to avoid unwanted moisture accumulation due to the product’s hygroscopic nature. Shelf life studies indicate that there is no loss of sweetness under normal storage condition for a wide range of products enhanced with Magnasweet. Additionally, no specific chemical incompatibilities or interactions have been identified between Magnasweet and common pharmaceutical active ingredients.

6. Pharmaceutical Applications VII. Use Levels Practical use levels vary widely depending on the product type, choice of flavoring and/or sweetening components, and the inherent flavor characteristics of the active ingredients. Determining optimal use levels is crucial and should be carefully considered in trail evaluations because Magnasweet products have their own characteristic sweetness and flavor. Generally, it is best to begin formulating at very low levels increasing by small step-wise increments until the desired effect is achieved. In recognition of the complexities of pharmaceutical flavoring, MAFCO Worldwide Corporation welcomes you to submit project to our application labs. Masking and debittering projects are our specialty. We’ll be glad to work with you in selecting the best Magnasweet product for your application, suggest suitable adjuncts, and determine the most desirable use levels. All work is done in strict confidence. Of course, if you prefer to conduct your own evaluation, we welcome the opportunity to provide you with samples and information

7. Pharmaceutical Applications VIII. Applications The applications for Magnasweet products are as carried as the range of consumer products available on the market. The following information is supplied to suggest areas where Magnasweet products have been found particularly beneficial. • Syrups: • Removed bitterness in cough/Cold preparations • Reduce the harshness of alcohol based oral antiseptics • Reduce bitterness in oral antibiotics • Improve flavor and palatability of pediatric syrup • Chewable: • Improve flavor and delivery of antacid tablets • Reduce bitterness in chewable APAP • Improve sweetness and flavor in chewable aspirin • Improve Flavor of laxative and antiflavulent tablets • Powders • Improve flavor and mouth feel in bulk laxatives • Improve flavor in antacid preparations • Lozenges: • Mask medicinal character of cough drops • Vitamins: • Mask vitamin aftertaste in multivitamins • Reduce iron taste in chewable with iron • Round flavor character of chewable Vitamin C • Improve flavor in chewable calcium supplements • Improve flavor in pediatric multivitamin syrups • Other: • All other prescription and non-prescription pharmaceuticals of oral administration where taste is a factor IX. Regulatory Status Monoammonium Glycyrrhizinate is listed as GRAS by FDA under the Code of Federal Regulations, parts 21, 184.1408.

8. Pharmaceutical Applications X. Technical Assistance MAFCO Worldwide Corporation has established a fully operational R&D laboratory at our facilities in New Jersey. Our technical personnel are qualified to assist in all facets of development including formulation, regulatory compliance, quality integration and validation, and labeling. It is our sincere wish that you take full advantage of our services and accept our assurance that you can do so in a cooperative and confidential environment. MAFCO Worldwide Corporation brings to you more than a century of experience as the world’s leading manufacturer of licorice products and derivatives. This experience, plus our well-stocked inventory assures you of a steady and reliable supply of Magnasweet products. MAFCO’s emphasis on excellence is based on a company tradition that dates back to 1850. So when you specify products you can be sure you are getting the same quality service and integrity that has kept our customer coming back year after year. For more information, please contact us at: MAFCO Worldwide Corporation Third Street & Jefferson Avenue Camden, NJ 08104, USA Phone: 856-964-8840 Fax: 856-964-6029 Email: magnasweet@mafcolicorice.com