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Lipids, Polyketides, Nonribosomal peptide synthesis

Lipid? What's a lipid?. Definition is difficult:Any molecule that is highly soluble in organic solvents."One class of aliphatic hydrocarbon-containing organic compounds essential for the structure and function of living cells... water-insoluble but soluble in nonpolar organic solvents."Fa

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Lipids, Polyketides, Nonribosomal peptide synthesis

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    1. Lipids, Polyketides, Nonribosomal peptide synthesis

    2. Lipid? What’s a lipid?

    3. Classes of lipids

    4. Examples of lipids

    5. Triacylglycerols

    6. Triglyceride = fat

    7. Fat is good

    8. Fatty acids

    9. Cis- vs. trans- unsaturated fatty acids

    10. Roles of fatty acids

    11. Fatty acid degradation -- b oxidation

    13. b-oxidation of fatty acids

    15. Energy yield of b-oxidation

    16. b-oxidation -- but what about………..

    17. Odd chain fatty acids

    18. Unsaturated fatty acids

    19. b-oxidation enzymology

    20. Fatty acid synthesis differs from degradation

    21. The acyl carrier protein Carrier of intermediates in fatty acid synthesis a 77 residue protein in E.coli - with a phosphopantetheine In terms of function, it’s a large CoA

    23. Type I vs. type II fatty acid synthases

    24. Lipidomics

    25. Tools of lipidomics

    26. Non-ribosomal peptides and polyketides

    27. PKs and NRPs have remarkable bioactivities

    28. Examples of PKs and NRPs

    29. Core biosynthesis of PKs and NRPs

    30. Modification reactions

    31. Synthesis of PKs and NRPs

    32. Polyketide synthases are modular

    33. NRP synthases are modular

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