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Plan for the coming years

Plan for the coming years. VELUX FONDEN. Why do we age so differently?. - D A N I S H A G I N G R E S E A R C H C E N T E R - www.sdu.dk/darc. Danish Aging Research Center. Greenhouse Project. Line Kirkeby Petersen, MD: Cholesterol and Aging Observational studies:

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Plan for the coming years

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  1. Plan for the coming years VELUX FONDEN Why do we age so differently? - D A N I S H A G I N G R E S E A R C H C E N T E R - www.sdu.dk/darc

  2. Danish Aging Research Center

  3. Greenhouse Project Line Kirkeby Petersen, MD: Cholesterol and Aging Observational studies: Low cholesterol good among younger elderly but associated with higher mortality among the Oldest-Old Clinical practice: Cholesterol lowering drugs áá

  4. Cholesterol and Mortality • 274 twin pairs age 73-94 • Blood samples 1997 • Follow-up to 2009 • Deaths:289 twins 244 pairs with at least one dead twin • Intrapair comparison: Control for age, sex, genetic factors

  5. 1905 Cohort - Denmark 314 Drop-outs 127 Drop-outs 58 Drop-outs 2,262 (63%) 1,086 (78%) 437 (77%) 166 (74%) 862 died 522 died 213 died 1998 2000 2003 2005

  6. 92 years – half way to 100 1:30 1:30 ♂ 0 92 100 1:10 1:10 0 92 100 ♀ 1:15 1:15 0 92 100 ♂ +♀

  7. PARAOXONASE 1 (PON) 1.00 0.75 0.50 0.25 0.00 0 1000 2000 3000 analysis time genotype = QQ genotype = QR genotype = RR Cross-sectional twin data show association Independent replication in 1905 cohort

  8. The Fourth Age Does exceptional longevity lead to exceptional levels of disability?

  9. Independence in the 1905-Cohort Christensen et al. PNAS, 2008

  10. Independence in the 1905-Cohort Christensen et al. PNAS, 2008

  11. The Failure of Success? 1895 1905 1915

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