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+ 7.13

control. + 7.13. + 7.13/CD44 low. + 7.13/CD44 high. MKN45. MKN45. MKN45. MKN45. MKN74. MKN74. MKN74. MKN74. #. *. 4000. 10. 8. MKN45. MKN45. 9. 3500. 7. MKN74. MKN74. 8. #. 3000. 6. 7. *. 2500. *. 5. 6. Fold change in invasion. Tumors volume in mice (mm 3 ).

sean-francis
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+ 7.13

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  1. control + 7.13 + 7.13/CD44low + 7.13/CD44high MKN45 MKN45 MKN45 MKN45 MKN74 MKN74 MKN74 MKN74 # * 4000 10 8 MKN45 MKN45 9 3500 7 MKN74 MKN74 8 # 3000 6 7 * 2500 * 5 6 Fold change in invasion Tumors volume in mice (mm3) 2000 5 4 4 # 1500 3 3 1000 2 2 500 1 1 0 0 0 Ctrl + 7.13 CD44low CD44high Ctrl + 7.13 CD44high CD44low Ctrl + 7.13 CD44low CD44high Ctrl + 7.13 20 CD44 * Snail1 18 Vimentin * 16 ZEB1 14 * 12 10 Relative mRNA level * 8 * * * 6 * 4 2 0 Ctrl + 7.13 Ctrl + 7.13 MKN-45 MKN-74 A C D B * 30 3,5 * * * * 3 25 # 2,5 20 * 2 Fold change in migration 15 Relative expression level of CD44 Fold induction of elongated cells * * 1,5 # 10 1 5 0,5 0 0 Ctrl + 7.13 CD44low CD44high Ctrl + 7.13 Ctrl Ctrl + 7.13 + 7.13 E F G * 70 * * 60 50 40 Number of spheroids # 30 20 * 10 0 Ctrl + 7.13 CD44low CD44high Ctrl + 7.13 H

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