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Synthesis and anti-bacterial, anti-fungal activity of novel 1,2,4-oxadiazole

Synthesis and anti-bacterial, anti-fungal activity of novel 1,2,4-oxadiazole

A series of novel 1, 2, 4-oxadiazole derivatives were synthesized and evaluated for in- vitro antibacterial and antifungal activity. All the compounds tested against bacteria showed comparable or less antibacterial activities than the reference drug. Differences in their activity depend on the substitution of different groups. More specifically, best antibacterial activityamong synthetic analogues was shown by compound 6 with MIC of 10 µg/ml and compound 14 with MIC of 50 µg/ml against Bacillus subtilis. All compounds tested showed significant antifungal activity against all the fungi, compared to the commercial fungicide Miconazole. Among them compounds 4 and 8 showed good antifungal activity against Fusarium solani with MIC of 10 and 50 µg/ml.

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Synthesis and biological evaluation of a novel series of methoxylated chalcones as antioxidant and anti-microbial agents

Synthesis and biological evaluation of a novel series of methoxylated chalcones as antioxidant and anti-microbial agents

A series of novel 2, 4, 5-trimethoxy Chalcones derivatives of biological interest were prepared by Claisen–Schmidt Condensation reaction. All the new compounds were evaluated for (1a-u) antioxidant (DPPH free radical scavenging activity) and antimicrobial (antifungal and antibacterial) activities against some selected pathogenic bacteria and fungi. Amongst all the 21 compounds screened, compounds 1b and 1o exhibited promising antioxidant activity (68 and 71% inhibition, as against standard BHA, 72 % inhibition ) while compounds 1c, 1d, 1j and 1k exhibited antibacterial and compounds 1c, 1j and 1k exhibited promising antifungal activity (MIC of 10-30 µg/ml). The structure–activity relationship (SAR) for all the above stated activities has also been represented.

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