Synthesis and characterization of 2-mercaptobenzimidazole derivatives as potential analgesic agents
In seeking broad spectrum pharmacological activities of 2-mercaptobenzimidazole moiety, a series of 2-mercaptobenzimidazole derivatives were synthesized by mannich reaction and screened for analgesic activity by hot plate method and tail flick method. Totally a series of ten new 2-mercaptobenzimidazole derivatives (1A-1J) were synthesized from 2- mercaptobenzimidazole by reaction with compounds having secondary amine and formaldehyde. The purity of the synthesized compounds was checked by melting point and TLC and their structure was established by various analytical techniques such as IR and 1HNMR spectral studies. All the synthesized compounds were exhibited significant analgesic activity when compared with standard drug, pentazocine. Key words: 2-Mercaptobenzimidazole, Manni
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