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1993 cell 75 817 - PowerPoint PPT Presentation

p53 gene mutations in human tumor s

p53 gene mutations in human tumor s. 50%. Greenblatt et al. (1995) Cancer Res . 54:4855. p53 and Ink4a are the two most frequently mutated genes in human tumors. The Basic Paradigm of p53 Function. Cellular Stresses (e.g. DNA damage). p53 (high). p53 (low). Apoptosis.

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1993 cell 75 817 - PowerPoint PPT Presentation

p53 gene mutations in human tumor s