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Synthesis, anticonvulsant and neurotoxicity of some novel 1,3,4-oxadiazole derivatives of phthalimide

Synthesis, anticonvulsant and neurotoxicity of some novel 1,3,4-oxadiazole derivatives of phthalimide

A series of novel 1,3,4-oxadiazole derivatives of phthalimide (4a-j) were prepared in satisfactory yields and evaluated for their anticonvulsant and neurotoxicity studies. All the compounds were in good agreement with elemental analysis and spectral data. All the compounds were active in MES screen and less neurotoxic than phenytoin. Compound 4j having methoxy substitution at para position of the distal aryl ring emerged as most promising anticonvulsant agent with low neurotoxicity.

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145 views • 10 slides
Synthesis, anticonvulsant and neurotoxicity of some novel 1,3,4-oxadiazole derivatives of phthalimide

Synthesis, anticonvulsant and neurotoxicity of some novel 1,3,4-oxadiazole derivatives of phthalimide

A series of novel 1,3,4-oxadiazole derivatives of phthalimide (4a-j) were prepared in satisfactory yields and evaluated for their anticonvulsant and neurotoxicity studies. All the compounds were in good agreement with elemental analysis and spectral data. All the compounds were active in MES screen and less neurotoxic than phenytoin. Compound 4j having methoxy substitution at para position of the distal aryl ring emerged as most promising anticonvulsant agent with low neurotoxicity.

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124 views • 10 slides
Role of Ketamine, Levetiracetam and LCarnitine in Aminophylline Induced Seizure in Wister Rat Model

Role of Ketamine, Levetiracetam and LCarnitine in Aminophylline Induced Seizure in Wister Rat Model

Aminophylline-induced seizure is commonly fatal and no specific, pharmacologically antagonistic drug is known. But recently, free radicals have been implicated in Aminophylline induced toxicities.

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93 views • 8 slides

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