Antimicrobial activities of synthesized and characterized 5-acetyl pyrimidine-2, 4, 6-(1H, 3H, 5H)-trione based chalcone
A series of eleven 5-((E)-3-phenylacryloyl) pyrimidine-2, 4, 6-(1H, 3H, 5H)-triones (5-acetyl pyrimidine 2, 4, 6-(1H, 3H, 5H) trione based chalcone) were synthesized using diethylmalonate, urea, acetic anhydride and various aryl aldehydes under basic conditions afforded the 5-acetyl pyrimidine-2, 4, 6-(1H, 3H, 5H)-trione based chalcone by means of Claisen–Schmidt condensation reaction. Furthermore, there has been some additional work investigating the effect of these derivatives on biological activity. They were characterized using FT-IR, 1H NMR spectroscopy and elemental analysis. The compounds show anti-fungal & antibacterial activity.
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