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Activated akt contributes - PowerPoint PPT Presentation

Developing Strategy for Next Generation of Antibody - Drug Conjugates

Comprised of a recombination monoclonal antibody and cytotoxic payloads through a linker, antibody drug conjugate (ADC) not only has highly cytotoxic antitumor effect of small molecule drugs, but also combines the high selectivity, stability and favorable pharmacokinetic characteristics of mAb.

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Akt inhibitor

Also known as GDC-0068, is a strong ATP-competitive pan-AKT inhibitor. It was initially derived during the screening and optimization process of a series of 6,7-dihydro-5H-cyclopenta[d]pyrimidine compounds. Ipatasertib shows a powerful inhibition of all protein kinase B (Akt) isoforms but a weak suppression towards other members of the protein kinase family.

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135 views • 10 slides

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Activated akt contributes - PowerPoint PPT Presentation

Developing Strategy for Next Generation of Antibody - Drug Conjugates

Akt inhibitor