'Active methylene group' presentation slideshows

Synthesis and antimicrobial activity of 3-cyano-4-imino-2-(methylthio)-7- methyl-4H-pyrido [1,2-a] pyrimidine derivative

The bis (methylthio) methylene malononitrile 1 on treatment with 2-amino 5-methyl pyridine 2 in N,N’-dimethyl formamide (DMF) and anhydrous potassium carbonate gives 3-cyano-4-imino-2-(methylthio)-7-methyl-4H-pyrido [1,2- a]pyrimidine 3.The latter were further reacted with selected N-, O- and C- nucleophiles such as aryl amines , heteryl amines, substituted phenols and compounds with an active methylene group

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