Spectrophotometric methodsfor estimation ofsimvastatin in bulk drug and its dosage form
Simple, accurate, precise, sensitive and selective spectrophotometric methods were developed for the estimation of simvastatin. The estimation ofsimvastatin was carried out by varioussolventslike ethanol (method I) at 238 nm, methanol (method II) at 235.8 nm. And these methods were found to be linear in the range of 5-30u00cfg/ml and 2-10 u00cfg/ml of simvastatin for method I and II, respectively. The percent amounts of simvastatin esti- mated by method I and method II were found to be 99.12% and 98.94, respectively. The developed method was validated according to ICH guidelines and it found to be accurate and precise.
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