'App superfamily shares' presentation slideshows

APP Processing and Plaque Formation

Canonical processing of APP is catalyzed by α-secretase, resulting in the generation of two fragments: a large extracellular fragment secreted APP (sAPP) α (sAPPα) that is released to extracellular medium, as well as an83 amino acid C-terminal fragment α-carboxyterminal fragments (CTF) that remains in the membrane.

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