'Compounds 3a' presentation slideshows

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Synthesis of New Substituted Thiazolidin-4-One Analogues with Anticancer and Antimicrobial Activity

Synthesis of New Substituted Thiazolidin-4-One Analogues with Anticancer and Antimicrobial Activity

The anticancer and antimicrobial activity associated with the thiazolidinone framework, several new (Z)-5-(substituted)-2-(methylthio) thiazol-4(5H)-one analogues 3a-l and 5a-l. All synthesized compounds were evaluated for anticancer and antimicrobial activity in vitro. Amongst these, the compounds 3c, 3f, 3h, 3j and 5a, 5c, 5d, 5e, 5f, 5h, 5j showed highest antibacterial and antifungal activity among the series. The compounds 3c and 5e exhibited significant antibacterial activity against E. coli, whereas compound 5f displayed significant antifungal activity against fungal strains i.e. A. oryzae. The in vitro anticancer studies revealed that 3i, 3k and 5b, 5k are the most active compounds against MCF-7 and BT-474 human breast cancer cell lines.

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145 views • 12 slides
Anticonvulsant and toxicity evaluation of newer 1-{(1-(2-substituted benzyl)-1H-benzo [d] imidazol-2-yl) methyl}-3-arylt

Anticonvulsant and toxicity evaluation of newer 1-{(1-(2-substituted benzyl)-1H-benzo [d] imidazol-2-yl) methyl}-3-arylt

A number of new 1-{(1-(2-substituted benzyl)-1H-benzo[d]imidazol-2-yl) methyl}-3- arylthioureas compounds (3a-p) were synthesized and evaluated for their anticonvulsant and neurotoxic properties. The titled compounds

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Synthesis and antimicrobial screening some new glycosyl-3-o-tolyl carbamides

Synthesis and antimicrobial screening some new glycosyl-3-o-tolyl carbamides

In recent years area of sugar urea derivatives has established considerable attention because of the unique structural properties and activities that these compounds display. The urea-linkage at the anomeric center is a robust alternative to the naturally occurring O- and N-glycosidic linkages of oligosaccharides and glycoconjugates, and the natural products that have been identified to contain these structures show remarkable biological activity.With these approach a series of new glycosyl-3-o-tolyl carbamides were synthesized by the interaction of various glycosylamines with o-tolylisothiocyanate. The compounds obtained were identified and characterized by their physical, spectral and elemental analysis data. The synthesized compounds were screened for their in vitro antimicrobial activity against bacteria (S. aureus, E. coli, P. aeruginosa) and fungi (A. niger, T. viride). Some of these compounds exhibited moderate to good activity, whereas some were inactive

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A Green Approach to Nitrogen Heterocycles : Application to Biologically Active Compounds

A Green Approach to Nitrogen Heterocycles : Application to Biologically Active Compounds

A Green Approach to Nitrogen Heterocycles : Application to Biologically Active Compounds. Background. Scheme 2 . ATRC of compound 3a using CuSO 4. Copper catalysed a tom transfer radical cyclisation (ATRC) was carried out for nitrogen heterocyclic synthesis .

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188 views • 1 slides

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