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Eprosartan - PowerPoint PPT Presentation

High Performance Liquid Chromatographic Analysis for Determination of Eprosartan Mesylate in Bulk Drug

A simple precise, accurate Reverse phase High performance liquid chromatographic method has been developed for the estimation of Eprosartan Mesylate in bulk. In this method a C18, 25 cm 5µ 4.6 mm ID (Oyster) column with mobile phase consisting of Sodium acetate buffer pH 3.0: Acetonitrile (70:30) was used. The detection wavelength is 235 nm and the flow rate is 1.0 ml/min. The linearity of Eprosartan shows regration coefficient of 0.9999. The proposed method is sufficiently selective to distinguish the parent drugs and the degradation products after hydrolysis photolysis or chemical oxidation.

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BP ? 130/80 - ? 150/90

Finish study. Responders (BP < 130/80). Monotherapy * Eprosartan 600 vs. Ramipril 5. BP ? 130/80 - ? 150/90. Non-responders (BP ? 130/80). Double-combination therapy * Eprosartan/HCTZ 600/12.5 vs. Ramipril/HCTZ 5/12.5. Hypertension

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141 views • 1 slides

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Eprosartan - PowerPoint PPT Presentation

High Performance Liquid Chromatographic Analysis for Determination of Eprosartan Mesylate in Bulk Drug

BP ? 130/80 - ? 150/90