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Rearrangements and Duplications in Tumor Genomes

Rearrangements and Duplications in Tumor Genomes. Chromosomal aberrations Structural : translocations, inversions, fissions, fusions. Copy number changes : gain and loss of chromosome arms, segmental duplications/deletions. Tumor Genomes. Mutation and selection. Compromised genome

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842 views • 62 slides

CSCI2950-C Lecture 9 Cancer Genomics

CSCI2950-C Lecture 9 Cancer Genomics. October 16, 2008 http://cs.brown.edu/courses/csci2950-c/. Outline. Cancer Genomes Paired-end Sequencing Rearrangements Comparative Genomic Hybridization. Single nucleotide change. Cell Division and Mutation. Copy number. Structural.

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454 views • 44 slides

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Es pairs - PowerPoint PPT Presentation

Rearrangements and Duplications in Tumor Genomes

CSCI2950-C Lecture 9 Cancer Genomics