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PRPS-1 is a regulative for neuroprotection and cells regenerative proliferation

Phosphoribosylpyrophosphate synthetase-1 (PRPS-1; EC 2.7.6.1) is the widely distributed in the human tissues and serves as a regulative key enzyme for purine metabolism, whereas Xanthine Oxidoreductase (XOR; EC 1.1.3.22) is the enzyme responsible for the catabolism of purine nucleotides and might by feed-back mechanism coordinate this entire biochemical pathway. We proposed activation of PRPS-1 and simultaneous inhibition of XOR might initiate regenerative processes after stroke.

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