'Lod scores' presentation slideshows

Linkage Analyisis II Phylogenic trees

Linkage Analyisis II Phylogenic trees. Goals. Given marker genes, we want to know the position of genes linked to a given phenotype. We use genes with multiple alleles (for the marker). For example a gene in which a SNP occurred and is present in some of the population.

847 views • 72 slides

Linkage Analyisis II Phylogenic trees

Linkage Analyisis II Phylogenic trees. Goals. Given marker genes, we want to know the position of genes linked to a given phenotype. We use genes with multiple alleles (for the marker). For example a gene in which a SNP occurred and is present in some of the population.

734 views • 72 slides

Nosce te ipsum: the human genome

714 views • 68 slides

AIMS OF WORKSHOP

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More About LOD Scores

More About LOD Scores. 2012. a) Relatedness. Backcross, F 2 , Recombinant inbred lines Humans: Need to be able to compare maps between groups Need suitable families for analysis - large, multigenerational. The Centre d'Etude du Polymorphism Humain (CEPH). Form P. Form Q. 1%. 99%. 15%.

429 views • 34 slides

Linkage Analysis: An Introduction

Linkage Analysis: An Introduction. Pak Sham Twin Workshop 2001. Linkage Mapping. Compares inheritance pattern of trait with the inheritance pattern of chromosomal regions First gene-mapping in 1913 (Sturtevant) Uses naturally occurring DNA variation (polymorphisms) as genetic markers

673 views • 33 slides

Linkage Analysis: An Introduction

Linkage Analysis: An Introduction. Pak Sham Twin Workshop 2001. Linkage Mapping. Compares inheritance pattern of trait with the inheritance pattern of chromosomal regions First gene-mapping in 1913 (Sturtevant) Uses naturally occurring DNA variation (polymorphisms) as genetic markers

601 views • 33 slides

Advanced Algorithms and Models for Computational Biology -- a machine learning approach

Advanced Algorithms and Models for Computational Biology -- a machine learning approach. Population Genetics: Quantitative Trait Locus (QTL) Mapping Eric Xing Lecture 17, March 22, 2006. Reading: DTW book, Chap 13. Phenotypical Traits. Body measures:

423 views • 29 slides

QTL mapping

566 views • 26 slides

Genetic Heterogeneity

Genetic Heterogeneity. Taken from: Advanced Topics in Linkage Analysis. Ch. 27 Presented by: Natalie Aizenberg Assaf Chen. Agenda. Motivation General approach to genetic heterogeneity. Allelic heterogeneity. Non-allelic heterogeneity. Test for homogeneity given Linkage.

400 views • 25 slides

Combining severity scores and organ dysfunction models improves the accuracy of prediction

408 views • 23 slides

Medical Genetics 1

Medical Genetics 1. Prof Duncan Shaw http://www.abdn.ac.uk/~gen155/djshome.html. Major Groups of Clinical Disorders with a Genetic Contribution. Single gene defects Chromosomal abnormalities Congenital malformations Multifactorial diseases - most common causes of illness.

327 views • 19 slides

Mapping genes with LOD score method

Mapping genes with LOD score method. LOD score method. Aim: Determine ? , the recombinant fraction (fraction of gametes that are recombinant), using data from relatively small families. Reminder: ? vary from 0 (2 genes completely linked) to 0.5 (2 genes are unlinked).

462 views • 16 slides