'Methyl insufficiency' presentation slideshows

SAM and SAH Analysis Service

It is now well established that deficiencies of the major dietary sources of methyl donors, methionine and choline, lead to the formation of liver cancer in rodents. Although not so widely studied as the liver tumors, extrahepatic tumor formation has also been increased in carcinogen-treated animals fed diets low in the methyl donors methionine, choline, and folic acid. Several plausible mechanisms have been proposed to explain the enhancing effects of dietary methyl deprivation on carcinogenesis. The most widely investigated, however, has been the idea that dietary methyl insufficiency results in abnormal DNA methylation subsequent to the formation of a physiological methyl insufficiency in vivo. A critical metabolite in the investigation of this hypothesis is SAM, the bodyu2019s chief physiological methyl donor.

35 views • 2 slides