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Mutation selection - PowerPoint PPT Presentation

Evolution Lectures 9,10,11: Population Genetics: Mutation, Migration and Drift (Chapter 7)

Evolution Lectures 9,10,11: Population Genetics: Mutation, Migration and Drift (Chapter 7). Mutation. Mutation adds variation to population It is, by itself not a powerful force Imagine we have the following freq:a=0.9 and A=0.1 Say, A is mutated to a at a rate of 1 copy/10,000 generations

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Is the CFTR allele maintained by mutation/selection balance?

Is the CFTR allele maintained by mutation/selection balance?. In some populations: Freq of Cystic Fibrosis: 2% Under mutation/selection balance, need: m = 4 x 10 -4 However the actual rate is 6.7 x 10 -7 too low!. Cultured mouse cells with CFTR genotypes . The fitness cost

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Mutation selection - PowerPoint PPT Presentation

Evolution Lectures 9,10,11: Population Genetics: Mutation, Migration and Drift (Chapter 7)

Is the CFTR allele maintained by mutation/selection balance?