'Nicardipine' presentation slideshows

Nicardipine - PowerPoint PPT Presentation

Uses Of Nicardipine Hydrochloride

Uses Of Nicardipine Hydrochloride

Nicardipine hydrochloride (Cardene) is a medication used to treat high blood pressure and angina. It belongs to the class of calcium channel blockers

★ ★ ★ ★ ★

395 views • 7 slides
Nicardipine induces apoptosis via IRE1 activation in the PC12 cells

Nicardipine induces apoptosis via IRE1 activation in the PC12 cells

Although an endoplasmic reticulum (ER) induction by calcium-channel blocker has been reported, the mechanism of ER stress-mediated apoptosis by nicardipine is unknown. Here, we demonstrated induction of apoptosis by nicardipine in PC12 cells. It was accompanied by the formation of apoptotic bodies via activation of ER-stress sensor, inositol-requiring enzyme 1 (IRE1). IRE1 induces the downregulation of key anti-apoptotic Bcl-2 expression in apoptosis. However, the altered expression of ER chaperones was not observed following nicardipine treatment. The results suggest that insight into the molecular mechanisms underlying nicardipineinduced apoptosis may facilitate the reduction of side effects and active treatment.

★ ★ ★ ★ ★

99 views • 4 slides
Nicardipine

Nicardipine

Nicardipine. Antihypertensive Drugs. Diuretics Beta blockers ACE-inhibitors Angiotensin II receptor blockers (ARB) Ca antagonist Verapamil Diltiazem Dihydropiridine (DHP) ? nifedipine, nicardipine. Katzung BG. Basic and clinical pharmacology. 10 th ed. USA: McGraw-Hill; 2006.

★ ★ ★ ★ ★

715 views • 3 slides
Control

Control

A. Control. TTX. 10 mV. 20 s. 1 Hz. 1 Hz. B. Control. Ctx GVIA. 1 Hz. 1 Hz. C. Control. Yohimbine. 0.5 Hz. 0.5 Hz. D. Control. Nicardipine. 0.5 Hz. 0.5 Hz.

★ ★ ★ ★ ★

120 views • 1 slides

View Nicardipine PowerPoint (PPT) presentations online in SlideServe. SlideServe has a very huge collection of Nicardipine PowerPoint presentations. You can view or download Nicardipine presentations for your school assignment or business presentation. Browse for the presentations on every topic that you want.