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Biotransformation of Xenobiotics

Biotransformation of Xenobiotics

Biotransformation of Xenobiotics. Overview. Phase I and Phase II enzymes Reaction mechanisms, substrates Enzyme inhibitors and inducers Genetic polymorphism Detoxification Metabolic activation. Introduction. Purpose Converts lipophilic to hydrophilic compounds Facilitates excretion

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1.06k views • 64 slides
Biotransformation of Xenobiotics

Biotransformation of Xenobiotics

Biotransformation of Xenobiotics. Overview. Phase I and Phase II enzymes Reaction mechanisms, substrates Enzyme inhibitors and inducers Genetic polymorphism Detoxification Metabolic activation. Introduction. Purpose Converts lipophilic to hydrophilic compounds Facilitates excretion

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866 views • 55 slides
METABOLISM / BIOTRANSFORMATION of TOXICANTS

METABOLISM / BIOTRANSFORMATION of TOXICANTS

METABOLISM / BIOTRANSFORMATION of TOXICANTS. Wongwiwat Tassaneeyakul Department of Toxicology Khon Kaen University. A D M E. ??????? (Xenobiotics). Highly lipophillic compounds. Lipophillic compounds. ????????????????. Phase I biotransformation (oxidation, reduction, hydrolysis ).

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1.33k views • 35 slides
METABOLISM / BIOTRANSFORMATION of TOXICANTS

METABOLISM / BIOTRANSFORMATION of TOXICANTS

METABOLISM / BIOTRANSFORMATION of TOXICANTS. Objectives. Definition of Xenobiotics. Xenobiotics routes of metabolism. Metabolic phases of metabolism discussing (PHASE I). Specific metabolic disorders. (Xenobiotics). Highly lipophillic compounds. Lipophillic compounds.

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527 views • 31 slides

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