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SHP-1 reverses trastuzumab resistance and migration in HER2-positive breast cancer cells through the stat3/p-stat3 pathw

Decreased expression of Src homology region 2 domain containing protein tyrosine phosphatase 1 (SHP-1) was found in human breast cancer cell lines and primary breast cancers. As a candidate tumor suppressor gene, the role of SHP-1 in HER-2-positive breast cancer remains to be elucidated. The aim of the present study was to investigate the effects of upregulated SHP-1 expression in reversing trastuzumab resistance and migration by HER-2-positive breast cancer cells, potentially providing a new target to trastuzumab resistance in anti-HER2 therapy.

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82 views • 7 slides

rPTPTD14

Classification of the vertebrate family of PTPs into Nontransmembrane (NT) and Receptor-like subtypes (R) based on PTP domain sequence homology. Subtypes. hPTPsigma ( PTPRS ). Inconsistent gene nomenclature is highlighted in red. mPTPsigma ( Ptprs ). PTPsigma. rPTPsigma ( Ptprd ).

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110 views • 1 slides

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Shp 1 - PowerPoint PPT Presentation

SHP-1 reverses trastuzumab resistance and migration in HER2-positive breast cancer cells through the stat3/p-stat3 pathw

rPTPTD14