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Synonymous polymorphisms - PowerPoint PPT Presentation

Rates and Fitness Effects of Mutations

Rates and Fitness Effects of Mutations. Adam Eyre-Walker (University of Sussex). -ve. +ve. 0. Types of Mutation. Deleterious Neutral Advantageous. K = 10% 10% sites mutated. K = 2% 80% mutations deleterious. DNA Sequence Data. Assume all mutations are neutral or deleterious.

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569 views • 47 slides

The Distribution of Fitness Effects of Mutations in Humans and Flies

The Distribution of Fitness Effects of Mutations in Humans and Flies. Adam Eyre-Walker (University of Sussex). -ve. +ve. 0. Types of Mutation. Deleterious Neutral Advantageous. Deleterious Mutations. Mutation accumulation and Mutagenesis expts. d n /d s in primates. <30%. <10%.

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314 views • 30 slides

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Synonymous polymorphisms - PowerPoint PPT Presentation

Rates and Fitness Effects of Mutations

The Distribution of Fitness Effects of Mutations in Humans and Flies