'Thymidylate synthase' presentation slideshows

On the evolution of thymidine synthesis: lateral gene transfer, viral involvement and early life

On the evolution of thymidine synthesis: lateral gene transfer, viral involvement and early life. Adi Stern Under the supervision of Tal Pupko. What makes DNA what it is? . Deoxy-nucleotides Thymidine. Thymidylate Synthase (Thy). Synthesizes dTMP (T), one of the DNA building blocks.

381 views • 37 slides

Discovery and Molecular Targets

Discovery and Molecular Targets. Susan Holbeck, Ph.D. National Cancer Institute Developmental Therapeutics Program Information Technology Branch holbecks@mail.nih.gov. NCI-DTP Drug Discovery Resources. NCI panel of 60 human tumor cell lines 2 day 5-dose growth inhibition assay

589 views • 32 slides

Archaeal extreme halophiles (halobacteria, haloarchaea)

671 views • 26 slides

Investigating conformation specific drug targets of human Thymidilate synthase

Investigating conformation specific drug targets of human Thymidilate synthase. Ukegbu B. Iroha Department of Pharmaceutical sciences, University of South Carolina, Columbia. Mentor: Dr. Sondra Berger December 10, 2004.

274 views • 13 slides

Nucleotide Degradation

284 views • 9 slides

180 views • 8 slides

Synthesis, molecular docking and ADME prediction of some pyridine and pyrimidine derivatives as anti-colorectal cancer d

Thymidylate synthase is the important enzyme used to generate thymidine monophosphate (dTMP), which is subsequently phosphorylated to thymidine triphosphate for use in DNA synthesis and repair.. Thymidylate synthase inhibitors are chemical agents which inhibit the enzyme Thymidylate synthase and have potential as an anti-colorectal cancer chemotherapy. Pyridine and Pyrimidine derivatives are found to be the potent inhibitors of Thymidylate synthase enzyme were rapidly identified. The molecular modeling aspects of the pyridine and pyrimidine derivatives are also presented.

143 views • 7 slides