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Quantitative determination of citalopram hydrobromide by spectro- photometry and chemometry in presence of its degradati

Quantitative determination of citalopram hydrobromide by spectro- photometry and chemometry in presence of its degradati

Simple, accurate, sensitive and validated UV stability-indicating spectro- photometric and chemometric methods were developed for determination of Citalopram Hydrobromide (CT) in presence of its alkaline, oxidative degradation products and in its pharmaceutical preparation. Method (A) is a successive derivative ratio spectrophotometricone, which depends on the successive derivative ofratio spectra in two steps and measuring Citalopram Hydrobromide at 277nm and 293nm. Method (B) is mean centering of ratio spectra which dependson using the mean centered ratio spectra in two successive steps and measuring the mean centeredvalues of the second ratio spectra at 237nm and method (C) used two chemometric techniques ; principal component regression(PCR) and partial least-squares (PLS). The proposed methods werechecked using laboratory-prepared mixtures and were successfully applied for the analysis of pharmaceuticalformulation containing Citalopram Hydrobromide. The proposed methods were vali- dated according to the ICH guidelines. The obtained results were statisti- cally compared with those obtained froma compendial HPLC method,showing no significant difference with respect to accuracy and precision.

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Five spectrophotometric methodsfor determination ofsulpride in pure form and pharmaceutical dosage form

Five spectrophotometric methodsfor determination ofsulpride in pure form and pharmaceutical dosage form

Five Simple, rapid, sensitive, accurate and precise stability-indicating spectrophotometric methods were developed for the determination of sulpride in bulk powder and in pharmaceutical preparation. Method (A) First derivative method( 1D), Method (B) Ratio derivative method( 1DD), Method (C) Ratio difference method, Method (D) Bivariate method and Method (E) Dual wavelength method are used for the determination of intact sulpride in presence of its degradation product. The methods were vali- dated and successfully applied to the determination of Dogmatil u00c6 50mg tablets. The obtained results were statistically compared with those of the reported method by applying t-test and F-test at 95% confidence level and no significant difference was observed regarding accuracy and preci- sion

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124 views • 10 slides

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